| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Berberine | 📋 | ✍ | ⛔ | | 38729776 | The combination of berberine and isoliquiritigenin synergistically improved adipose inflammation and obesity-induced insulin resistance |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38685284 | Vitamin D3 improves glucose metabolism and attenuates inflammation in prediabetic human and mice |
| Curcumin | 📋 | ✍ | ⛔ | | 38589346 | The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial |
| Resveratrol | 📋 | ✍ | ⛔ | | 38622329 | Resveratrol relieves HFD-induced insulin resistance in skeletal muscle tissue through antioxidant capacity enhancement and the Nrf2-Keap1 signaling pathway |
| Metformin | 📋 | ✍ | ⛔ | | 38463531 | Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity |
| Melatonin | 📋 | ✍ | ⛔ | | 38534314 | Melatonin Improves Glucose Homeostasis and Insulin Sensitivity by Mitigating Inflammation and Activating AMPK Signaling in a Mouse Model of Sleep Fragmentation |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38584606 | New approaches to triglyceride reduction: Is there any hope left? |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38707641 | Ginsenosides for the treatment of insulin resistance and diabetes: Therapeutic perspectives and mechanistic insights |
| Quercetin | 📋 | ✍ | ⛔ | | 38674793 | Quercetin Regulates Lipid Metabolism and Fat Accumulation by Regulating Inflammatory Responses and Glycometabolism Pathways: A Review |
| Mulberry | 📋 | | ⛔ | | 38555774 | Mulberry leaf and its effects against obesity: A systematic review of phytochemistry, molecular mechanisms and applications |
| Magnesium | 📋 | ✍ | ⛔ | | 38228168 | Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance |
| EGCG | 📋 | ✍ | ⛔ | | 38705537 | EGCG alleviates heat-stress-induced fat deposition by targeting HSP70 through activation of AMPK-SIRT1-PGC-1α in porcine subcutaneous preadipocytes |
| Cinnamon | 📋 | ✍ | ⛔ | | 38290699 | Effect of cinnamon spice on continuously monitored glycemic response in adults with prediabetes: a 4-week randomized controlled crossover trial |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 38367173 | Grape Seed Proanthocyanidins Protect Pancreatic β Cells Against Ferroptosis via the Nrf2 Pathway in Type 2 Diabetes |
| Red Yeast Rice | 📋 | ✍ | ⛔ | | 38480501 | Red Yeast Rice and Statin Therapy in Patients with Hypercholesterolemia and the Comorbidities: A Retrospective Cohort Study on Lipid-Lowering Effects and Cardiovascular Outcomes |
| Ginseng | 📋 | ✍ | ⛔ | | 38677706 | Ginseng polysaccharide components attenuate obesity and liver lipid accumulation by regulating fecal microbiota and hepatic lysine degradation |
| Anthocyanins | 📋 | ✍ | ⛔ | | 38387526 | Anthocyanins and their metabolites promote white adipose tissue beiging by regulating mitochondria thermogenesis and dynamics |
| Vitamin C | 📋 | ✍ | ⛔ | | 38493875 | Vitamins C, E, and beta-carotene and risk of type 2 diabetes: a systematic review and meta-analysis |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38393028 | Astaxanthin Inhibits H2O2-Induced Excessive Mitophagy and Apoptosis in SH-SY5Y Cells by Regulation of Akt/mTOR Activation |
| Cocoa | 📋 | ✍ | ⛔ | | 38694556 | Coffee, tea, and cocoa in obesity prevention: Mechanisms of action and future prospects |
| Fenugreek | 📋 | ✍ | ⛔ | | 37762302 | The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 38304787 | Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 38699871 | Alpha-Lipoic Acid Induces Adipose Tissue Browning through AMP-Activated Protein Kinase Signaling in Vivo and in Vitro |
| Fish Oil | 📋 | ✍ | ⛔ | | 38727803 | Fish oil supplementation during pregnancy decreases liver endocannabinoid system and lipogenic markers in newborn rats exposed to maternal high-fat diet |
| Blueberry | 📋 | ✍ | ⛔ | | 37528063 | Blueberry anthocyanins extract inhibits advanced glycation end-products (AGEs) production and AGEs-stimulated inflammation in RAW264.7 cells |
| Fucoidan | 📋 | ✍ | ⛔ | | 38410655 | Hypolipidemic effect of brown seaweed ( Sargassum crassifolium) extract in vivo (Study of histopathology, mRNA expression, and immunohistochemistry (IHC) with VCAM-1, ICAM-1, and MCP-1 parameters) |
| Spirulina | 📋 | ✍ | ⛔ | | 38694088 | Amino acid HPLC-FLD analysis of spirulina and its protective mechanism against the combination of obesity and colitis in wistar rats |
| CoQ10 | 📋 | ✍ | ⛔ | | 38203745 | Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview |
| Genistein | 📋 | ✍ | ⛔ | | 38504590 | Active Components of Pueraria lobata through the MAPK/ERK Signaling Pathway Alleviate Iron Overload in Alcoholic Liver Disease |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 36620201 | In Vitro Experimental Assessment of Ethanolic Extract of Moringa oleifera Leaves as an α-Amylase and α-Lipase Inhibitor |
| Phytochemicals | 📋 | | | | 38473918 | Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment |
| Pomegranate | 📋 | | ⛔ | | 38370057 | The effects of pomegranate consumption on obesity indices in adults: A systematic review and meta-analysis |
| Ginger | 📋 | ✍ | ⛔ | | 38474229 | The Effects of Body Fat Reduction through the Metabolic Control of Steam-Processed Ginger Extract in High-Fat-Diet-Fed Mice |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 38430822 | A green tea extract confection decreases circulating endotoxin and fasting glucose by improving gut barrier function but without affecting systemic inflammation: A double-blind, placebo-controlled randomized trial in healthy adults and adults with metabolic syndrome |
| Hesperidin | 📋 | ✍ | ⛔ | | 38577143 | Hesperidin Supplementation Improves Altered PON -1, LDL Oxidation, Inflammatory Response and Hepatic Function in an Experimental Rat Model of Hyperlipidemia |
| Olive Oil | 📋 | ✍ | ⛔ | | 38542768 | The Effects of Olive Oil Consumption on Biochemical Parameters and Body Mass Index of People with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 38649347 | Folic acid supplementation on inflammation and homocysteine in type 2 diabetes mellitus: systematic review and meta-analysis of randomized controlled trials |
| Lycopene | 📋 | ✍ | ⛔ | | 37165735 | Lycopene ameliorates islet function and down-regulates the TLR4/MyD88/NF-κB pathway in diabetic mice and Min6 cells |
| Naringenin | 📋 | ✍ | ⛔ | | 38272439 | Inhibitory effects of naringenin on estrogen deficiency-induced obesity via regulation of mitochondrial dynamics and AMPK activation associated with white adipose tissue browning |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 38027887 | The effect of ellagic acid on the metabolic syndrome: A review article |
| Green Tea | 📋 | ✍ | ⛔ | | 38494692 | Effects of coffee and tea on postprandial cardiometabolic risk factors in healthy individuals: a randomized crossover trial |
| Vitamin E | 📋 | ✍ | ⛔ | | 38493875 | Vitamins C, E, and beta-carotene and risk of type 2 diabetes: a systematic review and meta-analysis |
| L-Carnitine | 📋 | ✍ | ⛔ | | 38463531 | Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity |
| Sulforaphane | 📋 | ✍ | ⛔ | | 38611359 | Sulforaphane Ameliorates High-Fat-Diet-Induced Metabolic Abnormalities in Young and Middle-Aged Obese Male Mice |
| Polyphenols | 📋 | | | | 38588574 | Dietary Total Polyphenol, Flavonoid, and Lignan Intakes Are Associated with Obesity and Diabetes-Related Traits: A Case-Control Study |
| Walnut | 📋 | | ⛔ | | 38162665 | Walnut peptide alleviates obesity, inflammation and dyslipidemia in mice fed a high-fat diet by modulating the intestinal flora and metabolites |
| Almond | 📋 | | ⛔ | | 36963852 | Premeal almond load decreases postprandial glycaemia, adiposity and reversed prediabetes to normoglycemia: A randomized controlled trial |
| L-Arginine | 📋 | ✍ | ⛔ | | 38060094 | The Emerging Role of Prediabetes and Its Management: Focus on L-Arginine and a Survey in Clinical Practice |
| Puerarin | 📋 | ✍ | ⛔ | | 38504590 | Active Components of Pueraria lobata through the MAPK/ERK Signaling Pathway Alleviate Iron Overload in Alcoholic Liver Disease |
| Zinc | 📋 | ✍ | ⛔ | | 38258780 | The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats |
| Medicinal Plants | 📋 | | | | 38415194 | Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 38201964 | Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition |
| Coffee | 📋 | ✍ | ⛔ | | 38703226 | Coffee consumption might be associated with lower potential risk and severity of metabolic syndrome: national health and nutrition examination survey 2003-2018 |
| Food | 📋 | | | | 38198459 | Ketogenic diet preserves muscle mass and strength in a mouse model of type 2 diabetes |
| Luteolin | 📋 | ✍ | ⛔ | | 37749346 | Modulation of PPAR-γ, SREBP-1c and inflammatory mediators by luteolin ameliorates β-cell dysfunction and renal damage in a rat model of type-2 diabetes mellitus |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 38571539 | Inhibitory effect of stinging nettle (Urtica dioica L.) extract on body weight gain in rats on a high-fat diet |
| Whey Protein | 📋 | ✍ | ⛔ | | 38076400 | Whey Protein Supplementation and Type 2 Diabetes Mellitus Risk Factors: An Umbrella Systematic Review of Randomized Controlled Trials |
| Pterostilbene | 📋 | ✍ | ⛔ | | 38403920 | Pterostilbene protects against H2 O2 -induced oxidative stress by regulating GAS6/Axl signaling in HL-1 cells |
| Roselle | 📋 | ✍ | ⛔ | | 37762512 | Effect of Hibiscus sabdariffa L. on the Metabolism of Arachidonic Acid in the Isolated Kidney of a Rat Model of Metabolic Syndrome |
| Saffron | 📋 | ✍ | ⛔ | | 38207245 | Safety evaluation of saffron extracts in early and established atherosclerotic New Zealand white rabbits |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 38589346 | The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial |
| Goji Berry | 📋 | ✍ | ⛔ | | 38628207 | Anthocyanins from Lycium ruthenicum Murray attenuates high-fat diet-induced hypercholesterolemia in ApoE-/- mice are related to the modulation of gut microbiota and the ratio of conjugated to unconjugated bile acids in fecal bile acid profile |
| Nobiletin | 📋 | ✍ | | | 37327385 | The clock-modulatory activity of Nobiletin suppresses adipogenesis via Wnt signaling |
| Selenium | 📋 | ✍ | ⛔ | | 38377660 | Dosage-effect of selenium supplementation on blood glucose and oxidative stress in type 2 diabetes mellitus and normal mice |
| Crocin | 📋 | ✍ | ⛔ | | 38233742 | Antidiabetic and antioxidant potential of Crocin in high-fat diet plus streptozotocin-induced type-2 diabetic rats |
| Probiotics | 📋 | ✍ | ⛔ | | 38474810 | Nutritional Approaches Targeting Gut Microbiota in Oxidative-Stress-Associated Metabolic Syndrome: Focus on Early Life Programming |
| Raspberry | 📋 | ✍ | ⛔ | | 38340928 | Raspberry polysaccharides attenuate hepatic inflammation and oxidative stress in diet-induced obese mice by enhancing butyrate-mediated intestinal barrier function |
| Apigenin | 📋 | ✍ | ⛔ | | 38629096 | Role of apigenin in targeting metabolic syndrome: A systematic review |
| Coptis Chinensis | 📋 | | ⛔ | | 38677575 | Mechanism of the components compatibility of Scutellariae Radix and Coptidis Rhizoma on mice with hyperlipidemia by regulating the Cyp4a family |
| Inulin | 📋 | ✍ | ⛔ | | 38140284 | Effect of Continuous Ingestion of Bifidobacteria and Inulin on Reducing Body Fat: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study |
| NMN | 📋 | ✍ | ⛔ | | 38703507 | Alleviation of hepatic insulin resistance and steatosis with NMN via improving endoplasmic reticulum-Mitochondria miscommunication in the liver of HFD mice |
| Piperine | 📋 | ✍ | ⛔ | | 38481895 | Studies on the Effect of Piperine on Hepatocyte Nuclear Factor 1 Alpha (HNF-1α) and Sterol Regulatory Element-Binding Protein 1c (SREBP-1c) Levels in High-Fat-Diet and Sucrose-Induced Type 2 Diabetes Mellitus Rats |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 38726394 | Pistachio green hull and pomegranate peel extracts as two natural antiglycation agents |
| Silymarin | 📋 | ✍ | ⛔ | | 38396727 | Silymarin Reduced Insulin Resistance in Non-Diabetic Women with Obesity |
| Micronutrients | 📋 | | ⛔ | | 38612580 | Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 37214729 | Effects of a Ganoderma lucidum Proteoglycan on Type 2 Diabetic Rats and the Recovery of Rat Pancreatic Islets |
| Chokeberry | 📋 | ✍ | ⛔ | | 35807867 | Chokeberry ( A. melanocarpa (Michx.) Elliott)-A Natural Product for Metabolic Disorders? |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 37952912 | Docosahexaenoic acid (DHA) inhibits abdominal fat accumulation by promoting adipocyte apoptosis through PPARγ-LC3-BNIP3 pathway-mediated mitophagy |
| Garlic | 📋 | ✍ | ⛔ | | 37959027 | Comparison of Efficacy of Fermented Garlic and Orlistat (Lipase Inhibitor) in Obesity Management Using an Experimental Rodent Model |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 37373163 | Improving Mitochondrial Function in Skeletal Muscle Contributes to the Amelioration of Insulin Resistance by Nicotinamide Riboside |
| Bergamot | 📋 | ✍ | ⛔ | | 37732063 | Metabolic and vascular effect of a new standardized bergamot phytocomplex: a three-arm, placebocontrolled, double-blind clinical trial |
| Gingerol | 📋 | ✍ | | | 38493545 | 6-Gingerol alleviates ectopic lipid deposition in skeletal muscle by regulating CD36 translocation and mitochondrial function |
| Grape | 📋 | | ⛔ | | 37993763 | Fruits and the Risk of Type 2 Diabetes: The Korean Genome and Epidemiology Study Cohort |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 37375586 | Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial |
| Rutin | 📋 | ✍ | ⛔ | | 38723008 | Modulatory effects of rutin and vitamin A on hyperglycemia induced glycation, oxidative stress and inflammation in high-fat-fructose diet animal model |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 38577880 | Sea Buckthorn Polyphenols Alleviate High-Fat-Diet-Induced Metabolic Disorders in Mice via Reprograming Hepatic Lipid Homeostasis Owing to Directly Targeting Fatty Acid Synthase |
| Catechins | 📋 | | | | 38461723 | (-)-Epicatechin ameliorates type 2 diabetes mellitus by reshaping the gut microbiota and Gut-Liver axis in GK rats |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 38217909 | Sunflower seed extract supplementation reduces body fat in adults with obesity: A double-blind, randomized, placebo-controlled trial |
| Maitake Mushrooms | 📋 | | ⛔ | | 37193332 | Long-term consumption of different doses of Grifola frondosa affects immunity and metabolism: correlation with intestinal mucosal microbiota and blood lipids |
| Turmeric | 📋 | ✍ | ⛔ | | 38347961 | Curcuma longa extract reduces serum inflammatory markers and postprandial hyperglycemia in healthy but borderline participants with overweight and glycemia in the normal/prediabetes range: a randomized, double-blind, and placebo-controlled trial |
| Apple | 📋 | | ⛔ | | 36983908 | Apple Peel Supplementation Potential in Metabolic Syndrome Prevention |
| Psyllium | 📋 | ✍ | ⛔ | | 38688104 | Plantago consumption significantly reduces total cholesterol and low-density lipoprotein cholesterol in adults: A systematic review and meta-analysis |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 37024732 | Theabrownin of raw and ripened pu-erh tea varies in the alleviation of HFD-induced obesity via the regulation of gut microbiota |
| Gallic Acid | 📋 | | ⛔ | | 37536400 | Gallic Acid as a Sestrin (SESN2) activator and potential obesity therapeutic agent: a molecular docking study |
| Strawberry | 📋 | ✍ | ⛔ | | 37462847 | The Hypoglycemic and Hypolipidemic Effects of Polyphenol-Rich Strawberry Juice on Diabetic Rats |
| Astragalus Root | 📋 | ✍ | ⛔ | | 38138520 | Study of the Mechanism of Astragali Radix in Treating Type 2 Diabetes Mellitus and Its Renal Protection Based on Enzyme Activity, Network Pharmacology, and Experimental Verification |
| Black Tea | 📋 | ✍ | ⛔ | | 37569222 | The Role of Green Tea on the Regulation of Gut Microbes and Prevention of High-Fat Diet-Induced Metabolic Syndrome in Mice |
| Blackcurrant | 📋 | ✍ | ⛔ | | 35293002 | The antioxidant, anti-inflammatory, and antiplatelet effects of Ribes rubrum L. fruit extract in the diabetic rats |
| Capsaicin | 📋 | ✍ | ⛔ | | 38700794 | Capsaicin reduces blood glucose and prevents prostate growth by regulating androgen, RAGE/IGF-1/Akt, TGF-β/Smad signalling pathway and reversing epithelial-mesenchymal transition in streptozotocin-induced diabetic mice |
| Coconut Oil | 📋 | | ⛔ | | 37893623 | Lipid Profile in Multiple Sclerosis: Functional Capacity and Therapeutic Potential of Its Regulation after Intervention with Epigallocatechin Gallate and Coconut Oil |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38015360 | Distinct Microbial Taxa Are Associated with LDL-Cholesterol Reduction after 12 Weeks of Lactobacillus plantarum Intake in Mild Hypercholesterolemia: Results of a Randomized Controlled Study |
| Licorice Root | 📋 | ✍ | ⛔ | | 38447833 | The polysaccharides from seeds of Glycyrrhiza uralensis ameliorate metabolic disorders and restructure gut microbiota in type 2 diabetic mice |
| Argan Oil | 📋 | ✍ | ⛔ | | 34068075 | In Vitro & In Vivo Anti-Hyperglycemic Potential of Saponins Cake and Argan Oil from Argania spinosa |
| Astragalosides | 📋 | ✍ | ⛔ | | 37366351 | Astragaloside IV regulates insulin resistance and inflammatory response of adipocytes via modulating miR-21/PTEN/PI3K/AKT signaling |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 38257186 | Improving the Effect of Ferulic Acid on Inflammation and Insulin Resistance by Regulating the JNK/ERK and NF-κB Pathways in TNF-α-Treated 3T3-L1 Adipocytes |
| Ginger extract | 📋 | ✍ | ⛔ | | 37631148 | Iron Chelation Property, Antioxidant Activity, and Hepatoprotective Effect of 6-Gingerol-Rich Ginger ( Zingiber officinale) Extract in Iron-Loaded Huh7 Cells |
| Lotus | 📋 | | ⛔ | | 38223811 | Response surface methodology based development of an optimized polyherbal formulation and evaluation of its anti-diabetic and anti-obesity potential in high-fat diet-induced obese mice |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 38397782 | The Role of Glutathione and Its Precursors in Type 2 Diabetes |
| Naringin | 📋 | ✍ | ⛔ | | 38428704 | Biological activities, Molecular mechanisms, and Clinical application of Naringin in Metabolic syndrome |
| Oats | 📋 | | ⛔ | | 38553358 | Use of ancient grains for the management of diabetes mellitus: A systematic review and meta-analysis |
| Peanut | 📋 | | ⛔ | | 38137244 | Effects of Peanuts and Pistachios on Gut Microbiota and Metabolic Syndrome: A Review |
| Cannabidiol | 📋 | ✍ | ⛔ | | 37486107 | Cannabidiol ameliorates inflammatory response partly by AGE-RAGE pathway in diabetic mice |
| Cranberry | 📋 | ✍ | ⛔ | | 38542695 | The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Kudzu Root | 📋 | ✍ | ⛔ | | 37802808 | [Effect and mechanism of Puerariae Lobatae Radix in alleviating insulin resistance in T2DM db/db mice based on intestinal flora] |
| Stevia | 📋 | ✍ | ⛔ | | 37836640 | Unlocking the Therapeutic Potential of Stevia rebaudiana Bertoni: A Natural Antiglycating Agent and Non-Toxic Support for HDF Cell Health |
| Taurine | 📋 | ✍ | ⛔ | | 38706565 | Untargeted metabolomics based on ultra-high performance liquid chromatography-mass spectrometry/MS reveals the lipid-lowering mechanism of taurine in hyperlipidemia mice |
| Baicalin | 📋 | ✍ | ⛔ | | 38612466 | Unveiling Anti-Diabetic Potential of Baicalin and Baicalein from Baikal Skullcap: LC-MS, In Silico, and In Vitro Studies |
| Chromium | 📋 | ✍ | ⛔ | | 38228168 | Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance |
| Flaxseed | 📋 | ✍ | ⛔ | | 37457161 | Cookies enriched with anethole and secoisolariciresinol diglucoside from flaxseed and fennel seeds improve hypercholesterolemia, lipid profile, and liver functions: A pilot study |
| Hawthorn | 📋 | ✍ | ⛔ | | 38482041 | Efficacy of traditional Chinese medicine containing hawthorn for hyperlipidemia: a systematic review and meta-analysis |
| Punicalagin | 📋 | ✍ | ⛔ | | 37282949 | [Punicalagin inhibits hepatic lipid deposition in obese mice via AMPK/ACC pathway] |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 38601120 | Preventing hyperhomocysteinemia using vitamin B6 supplementation in Givosiran-treated acute intermittent porphyria: Highlights from a case report and brief literature review |
| Avocado | 📋 | ✍ | ⛔ | | 38515346 | New insight of chemical constituents in Persea americana fruit against obesity via integrated pharmacology |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 38367596 | Direct oral and fiber-derived butyrate supplementation as an anti-obesity treatment via different targets |
| Caffeine | 📋 | ✍ | ⛔ | | 38339081 | Metabolic Insights into Caffeine's Anti-Adipogenic Effects: An Exploration through Intestinal Microbiota Modulation in Obesity |
| Cherry | 📋 | | ⛔ | | 38256272 | Cornelian Cherry ( Cornus mas L.) Fruit Extract Lowers SREBP-1c and C/EBPα in Liver and Alters Various PPAR-α, PPAR-γ, LXR-α Target Genes in Cholesterol-Rich Diet Rabbit Model |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 38532480 | Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway |
| Aloe Vera | 📋 | ✍ | ⛔ | | 37969667 | Effect of aloe vera juice on type 2 diabetes mellitus among Indian patients |
| Bee Propolis | 📋 | ✍ | ⛔ | | 37063322 | Propolis polyphenols: A review on the composition and anti-obesity mechanism of different types of propolis polyphenols |
| Chrysin | 📋 | ✍ | ⛔ | | 38432408 | Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats |
| Dandelion | 📋 | ✍ | ⛔ | | 38000580 | Taraxacum mongolicum polysaccharides promotespromote white adipocyte browning by regulating miR-134-3p via Akt/GSK-3β signalling |
| Hydroxytyrosol | 📋 | | | | 35406139 | Effect of Long-Term Hydroxytyrosol Administration on Body Weight, Fat Mass and Urine Metabolomics: A Randomized Double-Blind Prospective Human Study |
| Kaempferol | 📋 | ✍ | ⛔ | | 38713943 | Kaempferol efficacy in metabolic diseases: Molecular mechanisms of action in diabetes mellitus, obesity, non-alcoholic fatty liver disease, steatohepatitis, and atherosclerosis |
| Mangiferin | 📋 | | ⛔ | | 38533569 | Mangiferin, a Potential Supplement to Improve Metabolic Syndrome: Current Status and Future Opportunities |
| Oleuropein | 📋 | | | | 36647430 | Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway |
| Pine Bark | 📋 | ✍ | ⛔ | | 33610726 | Effect of French maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria |
| Salidroside | 📋 | | | | 37576042 | Salidroside alleviates diet-induced obesity and insulin resistance by activating Nrf2/ARE pathway and enhancing the thermogenesis of adipose tissues |
| Thymoquinone | 📋 | | ⛔ | | 38125651 | Thymoquinone mitigates obesity and diabetic parameters through regulation of major adipokines, key lipid metabolizing enzymes and AMPK/p-AMPK in diet-induced obese rats |
| TUDCA | 📋 | ✍ | ⛔ | | 37687178 | Metabolomics and Lipidomics Study Unveils the Impact of Tauroursodeoxycholic Acid on Hyperlipidemic Mice |
| Bitter Melon | 📋 | ✍ | ⛔ | | 38304787 | Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses |
| Fiber | 📋 | ✍ | ⛔ | | 38348948 | Complex insoluble dietary fiber alleviates obesity, liver steatosis, and modulates the gut microbiota in C57BL/6J mice fed a high-fat diet |
| Indian Gooseberry | 📋 | | ⛔ | | 38659208 | Phyllanthus emblica Fruit Improves Obesity by Reducing Appetite and Enhancing Mucosal Homeostasis via the Gut Microbiota-Brain-Liver Axis in HFD-Induced Leptin-Resistant Rats |
| Orange | 📋 | | ⛔ | | 38257135 | Effect of 100% Orange Juice and a Volume-Matched Sugar-Sweetened Drink on Subjective Appetite, Food Intake, and Glycemic Response in Adults |
| Silibinin | 📋 | ✍ | | | 38532152 | Protective Effect of Silibinin on Lipopolysaccharide-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyroptosis |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 38674824 | Conjugated Linoleic Acid Ameliorates High Fat-Induced Insulin Resistance via Regulating Gut Microbiota-Host Metabolic and Immunomodulatory Interactions |
| Fisetin | 📋 | ✍ | ⛔ | | 38168356 | Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APPNL-F/NL-F Mice |
| Flavonoids | 📋 | | ⛔ | | 37324738 | Flavonoids improve type 2 diabetes mellitus and its complications: a review |
| Pantethine | 📋 | ✍ | ⛔ | | 37194410 | Pantethine ameliorates recognition impairment in a mouse model of Alzheimer's disease by modulating cholesterol content and intestinal flora species |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 38081572 | Niacin treatment prevents bone loss in iron overload osteoporotic rats via activation of SIRT1 signaling pathway |
| Allicin | 📋 | ✍ | ⛔ | | 38044730 | [Effects of allicin on insulin resistance and free fatty acid levels in obese rats with periodontitis] |
| Burdock | 📋 | | ⛔ | | 38027866 | Arctium lappa L. roots inhibit the intestinal inflammation of dietary obese rats through TLR4/NF-κB pathway |
| Butyrate | 📋 | | ⛔ | | 38367596 | Direct oral and fiber-derived butyrate supplementation as an anti-obesity treatment via different targets |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 37831134 | Fucoxanthin extract ameliorates obesity associated with modulation of bile acid metabolism and gut microbiota in high-fat-diet fed mice |
| PUFA | 📋 | | | | 38613089 | Improvement in Visceral Adipose Tissue and LDL Cholesterol by High PUFA Intake: 1-Year Results of the NutriAct Trial |
| Quinoa | 📋 | | ⛔ | | 38223811 | Response surface methodology based development of an optimized polyherbal formulation and evaluation of its anti-diabetic and anti-obesity potential in high-fat diet-induced obese mice |
| Cinnamaldehyde | 📋 | | | | 38698047 | Cinnamaldehyde ameliorates STZ-induced diabetes through modulation of autophagic process in adipocyte and hepatic tissues on rats |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38611884 | The Lipophilic Extract from Ginkgo biloba L. Leaves Promotes Glucose Uptake and Alleviates Palmitate-Induced Insulin Resistance in C2C12 Myotubes |
| Apple Polyphenols | 📋 | | ⛔ | | 34935369 | Apple Polyphenols Extracts Ameliorate High Carbohydrate Diet-Induced Body Weight Gain by Regulating the Gut Microbiota and Appetite |
| Barley | 📋 | ✍ | ⛔ | | 37940671 | Beneficial glycaemic effects of high-amylose barley bread compared to wheat bread in type 2 diabetes |
| Beets | 📋 | ✍ | ⛔ | | 38541120 | Nephroprotective and Anti-Diabetic Potential of Beta vulgaris L. Root (Beetroot) Methanolic Extract in a Rat Model of Type 2 Diabetes Mellitus |
| Cordyceps | 📋 | ✍ | ⛔ | | 37599693 | Cordyceps cicadae polysaccharides alleviate hyperglycemia by regulating gut microbiota and its mmetabolites in high-fat diet/streptozocin-induced diabetic mice |
| Lemon Balm | 📋 | ✍ | ⛔ | | 38575930 | Effects of Melissa officinalis (lemon balm) consumption on serum lipid profile: a meta-analysis of randomized controlled trials |
| Papaya | 📋 | ✍ | ⛔ | | 38172797 | Supplementation of papaya leaf juice has beneficial effects on glucose homeostasis in high fat/high sugar-induced obese and prediabetic adult mice |
| Aged Garlic | 📋 | ✍ | ⛔ | | 37163777 | Aged black garlic (Allium sativum L.) and aged black elephant garlic (Allium ampeloprasum L.) alleviate obesity and attenuate obesity-induced muscle atrophy in diet-induced obese C57BL/6 mice |
| Andrographolide | 📋 | | | | 37987454 | TXNIP-NLRP3-GSDMD axis-mediated inflammation and pyroptosis of islet β-cells is involved in cigarette smoke-induced hyperglycemia, which is alleviated by andrographolide |
| Baicalein | 📋 | ✍ | ⛔ | | 38612466 | Unveiling Anti-Diabetic Potential of Baicalin and Baicalein from Baikal Skullcap: LC-MS, In Silico, and In Vitro Studies |
| Betaine | 📋 | ✍ | ⛔ | | 38667581 | Low Dietary Betaine Intake Is Associated with Increased Blood Cholesterol in Mexican Subjects |
| Bilberry | 📋 | ✍ | ⛔ | | 36232316 | Dried Bilberry ( Vaccinium myrtillus L.) Alleviates the Inflammation and Adverse Metabolic Effects Caused by a High-Fat Diet in a Mouse Model of Obesity |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 37119739 | The ameliorative effect of zinc acetate with caffeic acid in the animal model of type 2 diabetes |
| Nicotinamide | 📋 | ✍ | ⛔ | | 37854354 | The effects of NAD+ precursor (nicotinic acid and nicotinamide) supplementation on weight loss and related hormones: a systematic review and meta-regression analysis of randomized controlled trials |
| Onion | 📋 | ✍ | ⛔ | | 37576046 | Antiobesity effects of onion ( Allium cepa) in subjects with obesity: Systematic review and meta-analysis |
| Schisandra | 📋 | ✍ | ⛔ | | 38718889 | Petroleum ether extract of Schisandra sphenanthera prevents hyperglycemia and insulin resistance in association with modulation of sweet taste receptors and gut microbiota in T2DM rats |
| Star Fuit | 📋 | | ⛔ | | 32606871 | Protective Effect of Benzoquinone Isolated from the Roots of Averrhoa carambola L. on Streptozotocin-Induced Diabetic Mice by Inhibiting the TLR4/NF-κB Signaling Pathway |
| Acai Berry | 📋 | ✍ | ⛔ | | 34715092 | Açaí seed extract (ASE) rich in proanthocyanidins improves cardiovascular remodeling by increasing antioxidant response in obese high-fat diet-fed mice |
| Asiatic Acid | 📋 | | | | 37283103 | Asiatic acid improves insulin secretion of β cells in type 2 diabetes through TNF- α/Mfn2 pathway |
| L-Citrulline | 📋 | ✍ | ⛔ | | 38425278 | L-Citrulline Ameliorates Iron Metabolism and Mitochondrial Quality Control via Activating AMPK Pathway in Intestine and Improves Microbiota in Mice with Iron Overload |
| Lingonberry | 📋 | | ⛔ | | 34617546 | Aqueous extracts of lingonberry and blackberry leaves identified by high-content screening beneficially act on cholesterol metabolism |
| Mangosteen | 📋 | ✍ | ⛔ | | 37566462 | Garcinia mangostana Suppresses Triacylglycerol Synthesis in Hepatocytes and Enterocytes |
| Persimmon | 📋 | | ⛔ | | 38070815 | Hypoglycemic activity of immature persimmon (Diospyros kaki Thunb.) extracts and its inhibition mechanism for α-amylase and α-glucosidase |
| Tea | 📋 | | | | 38694556 | Coffee, tea, and cocoa in obesity prevention: Mechanisms of action and future prospects |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 38169018 | The neuropsychopharmacology of acetyl-L-carnitine (LAC): basic, translational and therapeutic implications |
| Cardamom | 📋 | ✍ | ⛔ | | 36835337 | Cardamom ( Elettaria cardamomum (L.) Maton) Seeds Intake Increases Energy Expenditure and Reduces Fat Mass in Mice by Modulating Neural Circuits That Regulate Adipose Tissue Lipolysis and Mitochondrial Oxidative Metabolism in Liver and Skeletal Muscle |
| Chlorella | 📋 | ✍ | ⛔ | | 35822300 | Chlorella unsaturated fatty acids suppress high-fat diet-induced obesity in C57/BL6J mice |
| GABA | 📋 | ✍ | ⛔ | | 38256069 | Anti-Obesity Effects of GABA in C57BL/6J Mice with High-Fat Diet-Induced Obesity and 3T3-L1 Adipocytes |
| Haritaki | 📋 | ✍ | ⛔ | | 37240813 | Treatment with Terminalia chebula Extract Reduces Insulin Resistance, Hyperglycemia and Improves SIRT1 Expression in Type 2 Diabetic Rats |
| Hesperetin | 📋 | | | | 37175783 | The Combination of Natural Molecules Naringenin, Hesperetin, Curcumin, Polydatin and Quercetin Synergistically Decreases SEMA3E Expression Levels and DPPIV Activity in In Vitro Models of Insulin Resistance |
| Pistachio | 📋 | ✍ | ⛔ | | 38726394 | Pistachio green hull and pomegranate peel extracts as two natural antiglycation agents |
| Sweet Potato | 📋 | | ⛔ | | 37509903 | Mechanism of Anti-Diabetic Activity from Sweet Potato ( Ipomoea batatas): A Systematic Review |
| Tetrahydrocurcumin | 📋 | ✍ | | | 37876615 | Short term effect of tetrahydrocurcumin on adipose angiogenesis in very high-fat diet-induced obesity mouse model |
| Yogurt | 📋 | | ⛔ | | 37811566 | Dairy intake and risk of type 2 diabetes: results of a large prospective cohort |
| Angelica | 📋 | ✍ | ⛔ | | 35335221 | Angelica gigas NAKAI and Its Active Compound, Decursin, Inhibit Cellular Injury as an Antioxidant by the Regulation of AMP-Activated Protein Kinase and YAP Signaling |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 38028980 | The improvement effect of apple cider vinegar as a functional food on anthropometric indices, blood glucose and lipid profile in diabetic patients: a randomized controlled clinical trial |
| Ashwagandha | 📋 | ✍ | ⛔ | | 33882957 | Improvements in HOMA indices and pancreatic endocrinal tissues in type 2-diabetic rats by DPP-4 inhibition and antioxidant potential of an ethanol fruit extract of Withania coagulans |
| Basil | 📋 | ✍ | ⛔ | | 35470646 | Ocimum basilicum alleviates blood glucose, lipid profile and iNOS in diabetes gestational rat model |
| Date | 📋 | | ⛔ | | 37333476 | Effect of Ajwa date pits powder ( Phoenix dactylifera L.) on body composition, lipid profile and blood pressure in patients with hyperlipidemia: A randomized clinical trial |
| Dihydroquercetin | 📋 | | | | 36558373 | Dihydroquercetin Supplementation Improved Hepatic Lipid Dysmetabolism Mediated by Gut Microbiota in High-Fat Diet (HFD)-Fed Mice |
| Emodin | 📋 | | ⛔ | | 38286356 | Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action |
| Graviola | 📋 | ✍ | ⛔ | | 37299522 | Annona muricate Extract Supplementation Contributes to Improve Aberrant Multi-Organ Energy Metabolism via Muscle-Brain Connectivity in Diabetic Mice |
| Guava | 📋 | | ⛔ | | 37722234 | Elucidation of anti-hyperglycemic activity of Psidium guajava L. leaves extract on streptozotocin induced neonatal diabetic Long-Evans rats |
| Kiwifruit | 📋 | ✍ | ⛔ | | 36014875 | Insoluble and Soluble Dietary Fibers from Kiwifruit ( Actinidia deliciosa) Modify Gut Microbiota to Alleviate High-Fat Diet and Streptozotocin-Induced TYPE 2 Diabetes in Rats |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 38123015 | Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia |
| Nuts | 📋 | | ⛔ | | 36904160 | Nuts, Energy Balance and Body Weight |
| Oolong Tea | 📋 | | ⛔ | | 37744823 | High Gamma-Aminobutyric Acid (GABA) Oolong Tea Alleviates High-Fat Diet-Induced Metabolic Disorders in Mice |
| Prebiotics | 📋 | ✍ | ⛔ | | 38474810 | Nutritional Approaches Targeting Gut Microbiota in Oxidative-Stress-Associated Metabolic Syndrome: Focus on Early Life Programming |
| Rice | 📋 | | ⛔ | | 36981226 | Composition, Microbiota, Mechanisms, and Anti-Obesity Properties of Rice Bran |
| Rosemary | 📋 | ✍ | ⛔ | | 38048548 | Ameliorative effects of aqueous extract from rosemary on oxidative stress and inflammation pathways caused by a high-fat diet in C57BL/6 mice |
| Sesamol | 📋 | | | | 37775709 | Sesamol Alleviates High-Fat Diet-Induced Hepatic Insulin Resistance in C57BL/6 J Mice Through AMPK Activation Mediated by Adipose Adiponectin |
| Tangeretin | 📋 | | | | 35017003 | Tangeretin prevents obesity by modulating systemic inflammation, fat browning, and gut microbiota in high-fat diet-induced obese C57BL/6 mice |
| Vitamin A | 📋 | ✍ | ⛔ | | 38723008 | Modulatory effects of rutin and vitamin A on hyperglycemia induced glycation, oxidative stress and inflammation in high-fat-fructose diet animal model |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 36256603 | Metolachlor Poisoning with Lactic Acidosis Improved by Thiamine Administration: A Case Report |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 36305114 | [Serum vitamin K2 level and its association with bone metabolism markers in 1 732 children] |
| White Tea | 📋 | | ⛔ | | 34620309 | Forecast of ameliorating effect of dietary flavonol consumption in white tea with or without aerobic training on type 2 diabetes (T2D) in females |
| Wormwood | 📋 | ✍ | ⛔ | | 38485514 | The effect of Artemisia annua L. aqueous and methanolic extracts on insulin signaling in liver of HFD/STZ diabetic mice |
| Andrographis | 📋 | ✍ | ⛔ | | 37878369 | Andrographis paniculata (Burm. f.) Nees extract ameliorates insulin resistance in the insulin-resistant HepG2 cells via GLUT2/IRS-1 pathway |
| Antioxidants | 📋 | | ⛔ | | 38487634 | Linear association of compound dietary antioxidant index with hyperlipidemia: a cross-sectional study |
| Barberry | 📋 | ✍ | ⛔ | | 35579124 | Berberis aristata DC Extract Counteracts the High Fat Diet Induced Reproductive Toxicity in Female Wistar Rats via Modulating Oxidative Stress and Resistance to Leptin and Insulin |
| Blackberry | 📋 | | ⛔ | | 34617546 | Aqueous extracts of lingonberry and blackberry leaves identified by high-content screening beneficially act on cholesterol metabolism |
| Chia Seeds | 📋 | | ⛔ | | 38223811 | Response surface methodology based development of an optimized polyherbal formulation and evaluation of its anti-diabetic and anti-obesity potential in high-fat diet-induced obese mice |
| Cyanidin | 📋 | ✍ | | | 38387526 | Anthocyanins and their metabolites promote white adipose tissue beiging by regulating mitochondria thermogenesis and dynamics |
| Fig | 📋 | | ⛔ | | 37416794 | AGEs Blockerâ„¢ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice |
| Mango Leaf | 📋 | | ⛔ | | 37218883 | Assessing Anti-Adipogenic Effects of Mango Leaf Tea and Mangiferin within Cultured Adipocytes |
| Procyanidins | 📋 | | ⛔ | | 37803795 | Peanut skin procyanidins reduce intestinal glucose transport protein expression, regulate serum metabolites and ameliorate hyperglycemia in diabetic mice |
| Theabrownins | 📋 | | | | 38563324 | Theabrownin from Fu Brick tea ameliorates high-fat induced insulin resistance, hepatic steatosis, and inflammation in mice by altering the composition and metabolites of gut microbiota |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 38309487 | In-depth investigation of the therapeutic effect of Tribulus terrestris L. on type 2 diabetes based on intestinal microbiota and feces metabolomics |
| Carnosic Acid | 📋 | | | | 35844908 | Alteration of gut microbiota in high-fat diet-induced obese mice using carnosic acid from rosemary |
| Crocetin | 📋 | | | | 38386043 | Comparative pharmacokinetic investigation on crocetin in hyperlipidemia and normal rats after oral administration |
| Diosmin | 📋 | ✍ | ⛔ | | 36841479 | Selective PPARγ modulator Diosmin improves insulin sensitivity and promotes browning of white fat |
| Galangal | 📋 | ✍ | ⛔ | | 36818229 | Investigation of the Potential Mechanism of Alpinia officinarum Hance in Improving Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking |
| Guggul | 📋 | ✍ | ⛔ | | 37516016 | In-vivo anti-diabetic and anti-hyperlipidemic effects of natural metabolites from resin of Commiphora mukul and their in-silico to in-vitro target fishing |
| Krill Oil | 📋 | ✍ | ⛔ | | 37823164 | Krill oil inhibited adipogenic differentiation by inducing the nuclear Nrf2 expression and the AMPK activity |
| L-Glutamine | 📋 | ✍ | ⛔ | | 37847053 | Glutamine Ameliorates Liver Steatosis via Regulation of Glycolipid Metabolism and Gut Microbiota in High-Fat Diet-Induced Obese Mice |
| L-Leucine | 📋 | ✍ | ⛔ | | 38534346 | Leucine Supplementation Prevents the Development of Skeletal Muscle Dysfunction in a Rat Model of HFpEF |
| Milk Thistle | 📋 | ✍ | ⛔ | | 37974616 | Preventive and Therapeutic Effects of Silybum marianum Seed Extract Rich in Silydianin and Silychristin in a Rat Model of Metabolic Syndrome |
| Neem | 📋 | ✍ | | | 36861235 | Combating effects of Azadirachta indica leaves extract on biochemical and neuropsychological decline observed in diabetes |
| Nuciferine | 📋 | | | | 38175708 | Nuciferine prevents obesity by activating brown adipose tissue |
| Okra | 📋 | | ⛔ | | 38466075 | Molecular docking and in vivo protective effects of okra ( Abelmoschus esculentus) against metabolic dysfunction in high-fat, high-sodium diet-fed rats |
| Pomegranate Seed extract | 📋 | | ⛔ | | 33302270 | Efficacy of Pomegranate Seed Powder on Glucose and Lipid Metabolism in Patients with Type 2 Diabetes: A Prospective Randomized Double-Blind Placebo-Controlled Clinical Trial |
| Seaweeds | 📋 | | ⛔ | | 38410655 | Hypolipidemic effect of brown seaweed ( Sargassum crassifolium) extract in vivo (Study of histopathology, mRNA expression, and immunohistochemistry (IHC) with VCAM-1, ICAM-1, and MCP-1 parameters) |
| Skullcap | 📋 | ✍ | ⛔ | | 38677575 | Mechanism of the components compatibility of Scutellariae Radix and Coptidis Rhizoma on mice with hyperlipidemia by regulating the Cyp4a family |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 36383150 | Dietary Soy Isoflavones Prevent Metabolic Disturbs Associated with a Deleterious Combination of Obesity and Menopause |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 34794202 | An exploratory double-blind, randomized, placebo-controlled study to assess the efficacy of CitruSlim on body composition and lipid parameters in obese individuals |
| Trehalose | 📋 | | ⛔ | | 38058700 | The effects of oral trehalose on glycaemia, inflammation, and quality of life in patients with type 2 diabetes: a pilot randomized controlled trial |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 37693081 | Effect of β-sitosterol on insulin resistance & protein expression of insulin signalling molecules in quadriceps muscle of high fat diet-induced type-2 diabetic rats |
| Buckwheat | 📋 | | ⛔ | | 37655471 | Fagopyrum tataricum ethanol extract ameliorates symptoms of hyperglycemia by regulating gut microbiota in type 2 diabetes mellitus mice |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 38628208 | Study of active components and mechanisms mediating the hypolipidemic effect of Inonotus obliquus polysaccharides |
| Chamomile | 📋 | ✍ | ⛔ | | 36160451 | Integrating experimental model, LC-MS/MS chemical analysis, and systems biology approach to investigate the possible antidiabetic effect and mechanisms of Matricaria aurea (Golden Chamomile) in type 2 diabetes mellitus |
| Folate | 📋 | ✍ | ⛔ | | 38201964 | Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition |
| Frankincense | 📋 | ✍ | ⛔ | | 34542667 | Potential therapeutic effects of boswellic acids/Boswellia serrata extract in the prevention and therapy of type 2 diabetes and Alzheimer's disease |
| Holy Basil | 📋 | ✍ | ⛔ | | 33327808 | Iron modulatory property of a polysaccharide from Indian medicinal plant Ocimum sanctum |
| L-Carnosine | 📋 | ✍ | ⛔ | | 38172006 | Carnosine supplementation improves glucose control in adults with pre-diabetes and type 2 diabetes: A randomised controlled trial |
| Lutein | 📋 | ✍ | ⛔ | | 36086831 | Lutein ameliorates high-fat diet-induced obesity, fatty liver, and glucose intolerance in C57BL/6J mice |
| Myricetin | 📋 | | ⛔ | | 37305094 | Therapeutic potential of multifunctional myricetin for treatment of type 2 diabetes mellitus |
| Olive Polyphenols | 📋 | | | | 38132869 | Olive Oil Polyphenols Improve HDL Cholesterol and Promote Maintenance of Lipid Metabolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Pumpkin | 📋 | | ⛔ | | 35959224 | In Vitro Role of Pumpkin Parts as Pharma-Foods: Antihyperglycemic and Antihyperlipidemic Activities of Pumpkin Peel, Flesh, and Seed Powders, in Alloxan-Induced Diabetic Rats |
| Rosmarinic Acid | 📋 | ✍ | | | 36982168 | Muscle Cell Insulin Resistance Is Attenuated by Rosmarinic Acid: Elucidating the Mechanisms Involved |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 37803584 | Shiitake polysaccharides acted as a non-competitive inhibitor to α-glucosidase and inhibited glucose transport of digested starch from Caco-2 cells monolayer |
| Soy | 📋 | ✍ | ⛔ | | 38342411 | Effect of unfermented soy product consumption on blood lipids in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 37147641 | Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites |
| Arjuna | 📋 | ✍ | ⛔ | | 35739183 | Terminalia catappa aqueous leaf extract reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/streptozotocin-induced diabetic rats |
| Artichoke | 📋 | ✍ | ⛔ | | 38102588 | Artichoke (Cynara scolymus L.) water extract alleviates palmitate-induced insulin resistance in HepG2 hepatocytes via the activation of IRS1/PI3K/AKT/FoxO1 and GSK-3β signaling pathway |
| Berries | 📋 | | | | 37111125 | Berry Dietary Interventions in Metabolic Syndrome: New Insights |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 38493875 | Vitamins C, E, and beta-carotene and risk of type 2 diabetes: a systematic review and meta-analysis |
| Black Pepper | 📋 | ✍ | ⛔ | | 37237954 | Black Pepper ( Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent against Neurodegenerative Diseases |
| Camellia | 📋 | | ⛔ | | 38606255 | Modulation of Oxidative Stress and Glycemic Control in Diabetic Wistar Rats: The Therapeutic Potential of Theobroma cacao and Camellia sinensis Diets |
| Dairy | 📋 | | | | 38232682 | The effect of dairy products on liver fat and metabolic risk markers in males with abdominal obesity - a four-arm randomized controlled trial |
| DHEA | 📋 | ✍ | ⛔ | | 33771656 | DHEA-pretreatment attenuates oxidative stress in kidney-cortex and liver of diabetic rabbits and delays development of the disease |
| Egg | 📋 | | ⛔ | | 37686779 | Consumption of Different Egg-Based Diets Alters Clinical Metabolic and Hematological Parameters in Young, Healthy Men and Women |
| Elderberry | 📋 | ✍ | ⛔ | | 31398785 | Elderberry ( Sambucus nigra L.) Fruit Extract Alleviates Oxidative Stress, Insulin Resistance, and Inflammation in Hypertrophied 3T3-L1 Adipocytes and Activated RAW 264.7 Macrophages |
| Eugenol | 📋 | | | | 38005341 | Anti-Inflammatory Properties of Eugenol in Lipopolysaccharide-Induced Macrophages and Its Role in Preventing β-Cell Dedifferentiation and Loss Induced by High Glucose-High Lipid Conditions |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 38039598 | Dietary flaxseed oil induces production of adiponectin in visceral fat and prevents obesity in mice |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 35562092 | Role of polyphenols from Polygonum multiflorum Caulis in obesity-related disorders |
| Forskolin | 📋 | ✍ | ⛔ | | 33804418 | Effect of Forskolin on Body Weight, Glucose Metabolism and Adipocyte Size of Diet-Induced Obesity in Mice |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 25599391 | Helichrysum and Grapefruit Extracts Boost Weight Loss in Overweight Rats Reducing Inflammation |
| Isoliquiritigenin | 📋 | | | | 38729776 | The combination of berberine and isoliquiritigenin synergistically improved adipose inflammation and obesity-induced insulin resistance |
| Loquat | 📋 | ✍ | ⛔ | | 37498560 | Polyphenol-rich extract from loquat fruit peel prevents hyperlipidemia and hepato-nephrotoxicity in mice: in vivo study and in silico prediction of possible mechanisms involving identified polyphenols and/or their circulating metabolites |
| Milk | 📋 | | ⛔ | | 38342541 | Mechanisms by which sheep milk consumption ameliorates insulin resistance in high-fat diet-fed mice |
| Myrrh | 📋 | ✍ | ⛔ | | 32829055 | Commiphora myrrha stimulates insulin secretion from mouse and human islets of Langerhans |
| Nutmeg | 📋 | ✍ | ⛔ | | 35565666 | Myristica fragrans Extract Regulates Gut Microbes and Metabolites to Attenuate Hepatic Inflammation and Lipid Metabolism Disorders via the AhR-FAS and NF-κB Signaling Pathways in Mice with Non-Alcoholic Fatty Liver Disease |
| Oleic Acid | 📋 | | ⛔ | | 37944523 | Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury |
| Proanthocyanidins | 📋 | | | | 37298181 | Catechins and Proanthocyanidins Involvement in Metabolic Syndrome |
| Spikenard | 📋 | ✍ | ⛔ | | 30668444 | Secondary metabolite profiling, cytotoxicity, anti-inflammatory potential and in vitro inhibitory activities of Nardostachys jatamansi on key enzymes linked to hyperglycemia, hypertension and cognitive disorders |
| Theaflavins | 📋 | ✍ | | | 38550892 | Potential anti-hyperglycemic activity of black tea theaflavins through inhibiting α-amylase |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 36160891 | Riboflavin ameliorates mitochondrial dysfunction via the AMPK/PGC1α/HO‑1 signaling pathway and attenuates carbon tetrachloride‑induced liver fibrosis in rats |
| Yerba Mate | 📋 | ✍ | ⛔ | | 38327997 | Ilex paraguariensis A.St.-Hil. improves lipid metabolism in high-fat diet-fed obese rats and suppresses intracellular lipid accumulation in 3T3-L1 adipocytes via the AMPK-dependent and insulin signaling pathways |
| Avocado Oil | 📋 | | ⛔ | | 35889863 | Effects of Avocado Oil Supplementation on Insulin Sensitivity, Cognition, and Inflammatory and Oxidative Stress Markers in Different Tissues of Diet-Induced Obese Mice |
| Beta-Cryptoxanthin | 📋 | | | | 37571282 | Combined Ingestion of Tea Catechin and Citrus β-Cryptoxanthin Improves Liver Function via Adipokines in Chronic Obesity |
| Brazil Nut | 📋 | | ⛔ | | 38575248 | Brazil nut consumption reduces DNA damage in overweight type 2 diabetes mellitus patients |
| Choline | 📋 | ✍ | ⛔ | | 36973700 | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 36677639 | Analysis of Chemical Constituents of Chrysanthemum morifolium Extract and Its Effect on Postprandial Lipid Metabolism in Healthy Adults |
| Coconut | 📋 | | ⛔ | | 38475510 | Coconut ( Cocos nucifera (L.)) Water Improves Glucose Uptake with Concomitant Modulation of Antioxidant and Purinergic Activities in Isolated Rat Psoas Muscles |
| Daidzein | 📋 | ✍ | ⛔ | | 33899670 | Dietary isoflavones intake is inversely associated with non-alcoholic fatty liver disease, hyperlipidaemia and hypertension |
| Diosmetin | 📋 | | | | 38460078 | Diosmetin Ameliorates HFD-induced Cognitive Impairments via Inhibiting Metabolic Disorders, Mitochondrial Dysfunction and Neuroinflammation in Male SD Rats |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 37115805 | Glycyrrhizin ameliorates impaired glucose metabolism and ovarian dysfunction in a polycystic ovary syndrome mouse model |
| Helichrysum | 📋 | | ⛔ | | 35749144 | Helichrysum italicum (Roth) G. Don and Helichrysum arenarium (L.) Moench infusions in reversing the traits of metabolic syndrome: a double-blind randomized comparative trial |
| Kombucha | 📋 | ✍ | ⛔ | | 37588049 | Kombucha tea as an anti-hyperglycemic agent in humans with diabetes - a randomized controlled pilot investigation |
| L-Theanine | 📋 | ✍ | ⛔ | | 38677602 | L-theanine abates oxidative stress and mitochondrial dysfunction in myocardial ischemia-reperfusion injury by positively regulating the antioxidant response |
| Lauric Acid | 📋 | ✍ | | | 37211320 | Lauric acid improves hormonal profiles, antioxidant properties, sperm quality and histomorphometric changes in testis and epididymis of streptozotocin-induced diabetic infertility rats |
| Nattokinase | 📋 | ✍ | ⛔ | | 38586318 | Effect of nattokinase on the pathological conditions in streptozotocin induced diabetic rats |
| Oleanolic Acid | 📋 | | | | 38398510 | The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases |
| Plum | 📋 | | ⛔ | | 36721717 | Plum supplementation and lipid profile: a systematic review and meta-analysis of randomised controlled trials |
| Prickly Pear | 📋 | | ⛔ | | 37994760 | Unraveling the Role of Prickly Pear Extract as a Potent Nutraceutical Agent Against Metabolic Syndromes |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 35465120 | Effects of Pumpkin ( Cucurbita pepo L.) Seed Protein on Blood Pressure, Plasma Lipids, Leptin, Adiponectin, and Oxidative Stress in Rats with Fructose-Induced Metabolic Syndrome |
| Rhubarb | 📋 | | ⛔ | | 37808167 | Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review |
| Sage | 📋 | ✍ | ⛔ | | 37581324 | Salvia Officinalis Improves Glucose Uptake and Suppresses Ectopic Lipid Deposition in Obese Rats with Metabolic Syndrome |
| Salvianolic Acid | 📋 | | | | 37429233 | Protective benefits of salvianic acid A against retinal iron overload by inhibition of ferroptosis |
| Tanshinone | 📋 | | | | 37509065 | Tanshinone IIA and Cryptotanshinone Counteract Inflammation by Regulating Gene and miRNA Expression in Human SGBS Adipocytes |
| Telmisartan | 📋 | | ⛔ | | 38653362 | Telmisartan ameliorates nephropathy and restores the hippo pathway in rats with metabolic syndrome |
| Urolithins | 📋 | | | | 38411192 | Aging STINGs: mitophagy at the crossroads of neuroinflammation |
| Withaferin A | 📋 | | | | 35734936 | Modulatory action of withaferin-A on oxidative damage through regulation of inflammatory mediators and apoptosis via PI3K/AKT signaling pathway in high cholesterol-induced atherosclerosis in experimental rats |
| Wood Ear Mushrooms | 📋 | | ⛔ | | 38423908 | Potential inhibitory effect of Auricularia auricula polysaccharide on advanced glycation end-products (AGEs) |
| Acacetin | 📋 | | | | 36892720 | Acacetin attenuates the pancreatic and hepatorenal dysfunction in type 2 diabetic rats induced by high-fat diet combined with streptozotocin |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 38123015 | Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia |
| Amaranth | 📋 | | ⛔ | | 35796287 | Multigrain porridge possesses superior nutritional quality, its consumption alleviates hyperglycemia, hypercholesterolemia and oxidative stress in obese-diabetic wistar rats |
| Arctigenin | 📋 | | | | 36660596 | Arctigenin-containing burdock sprout extract prevents obesity in association with modulation of the gut microbiota in mice |
| Black Tea Polyphenols | 📋 | | | | 36176635 | Multiomic analysis of dark tea extract on glycolipid metabolic disorders in db/db mice |
| Broccoli | 📋 | | ⛔ | | 36145190 | Anti-Obesogenic Effects of Sulforaphane-Rich Broccoli ( Brassica oleracea var. italica) Sprouts and Myrosinase-Rich Mustard ( Sinapis alba L.) Seeds In Vitro and In Vivo |
| Carrot | 📋 | | ⛔ | | 34349520 | Carrot Juice Consumption Reduces High Fructose-Induced Adiposity in Rats and Body Weight and BMI in Type 2 Diabetic Subjects |
| Galangin | 📋 | | | | 37251824 | Mitigation effect of galangin against aortic dysfunction and hypertrophy in rats with metabolic syndrome |
| Gardenia | 📋 | | ⛔ | | 38539827 | Extract of Gardenia jasminoides Ellis Attenuates High-Fat Diet-Induced Glycolipid Metabolism Disorder in Rats by Targeting Gut Microbiota and TLR4/Myd88/NF-κB Pathway |
| Hazelnut | 📋 | | ⛔ | | 38043651 | Effects of hazelnut soluble dietary fiber on lipid-lowering and gut microbiota in high-fat-diet-fed rats |
| Honey | 📋 | ✍ | ⛔ | | 36379223 | Effect of honey on cardiometabolic risk factors: a systematic review and meta-analysis |
| Honokiol | 📋 | | | | 36508141 | Honokiol Reduces Mitochondrial Dysfunction and Inhibits Apoptosis of Nerve Cells in Rats with Traumatic Brain Injury by Activating the Mitochondrial Unfolded Protein Response |
| Irisin | 📋 | | | | 38137532 | Irisin Enhances Mitochondrial Function in Osteoclast Progenitors during Differentiation |
| Isorhamnetin | 📋 | | | | 38445617 | Isorhamnetin as a potential therapeutic agent for diabetes mellitus through PGK1/AKT activation |
| Knotweed | 📋 | ✍ | ⛔ | | 36815210 | Ultra-high performance liquid chromatography- quadrupole/ time-of-flight mass spectrometry based lipidomics reveals key lipid molecules as potential therapeutic targets of Polygonum cuspidatum against hyperlipidemia in a hamster model |
| Lemon | 📋 | | ⛔ | | 35484880 | Anti-obesity effect of fermented lemon peel on high-fat diet-induced obese mice by modulating the inflammatory response |
| Lemon Verbena | 📋 | | ⛔ | | 34591168 | Effectiveness of a polyphenolic extract (Lippia citriodora and Hibiscus sabdariffa) on appetite regulation in overweight and obese grade I population: an 8-week randomized, double-blind, cross-over, placebo-controlled trial |
| Mango | 📋 | | ⛔ | | 36841190 | Antidiabetic properties of mango in animal models and humans: A systematic review |
| NAD | 📋 | | | | 37761000 | The Role of NAD+ in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance |
| Paeoniflorin | 📋 | | | | 36510583 | Paeoniflorin, a constituent of Kami-shoyo-san, suppresses blood glucose levels in postmenopausal diabetic mice by promoting the secretion of estradiol from adipocytes |
| Phloretin | 📋 | | | | 37023949 | Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice |
| Polydatin | 📋 | ✍ | | | 38323270 | Polydatin ameliorates low-density lipoprotein cholesterol and lipid metabolism by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9) in triple-negative breast cancer with hyperlipidemia |
| PQQ | 📋 | ✍ | ⛔ | | 37214340 | Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression |
| Red Sage | 📋 | ✍ | ⛔ | | 36820318 | Combined Network Pharmacology and Molecular Docking to Verify the Treatment of Type 2 Diabetes with Pueraria Lobata Radix and Salviae Miltiorrhizae Radix |
| Royal Jelly | 📋 | ✍ | ⛔ | | 38337678 | Exploring the Therapeutic Potential of Royal Jelly in Metabolic Disorders and Gastrointestinal Diseases |
| Sesame | 📋 | ✍ | ⛔ | | 38316576 | Effect of sesame supplementation on body composition and lipid profile in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials |
| Sesamin | 📋 | ✍ | | | 38228077 | Sesamin and sesamolin potentially inhibit adipogenesis through downregulating the peroxisome proliferator-activated receptor γ protein expression and activity in 3T3-L1 cells |
| Soy Protein | 📋 | ✍ | ⛔ | | 38174000 | Protein supplementation: the double-edged sword |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 36336219 | Hypericum perforatum L. extract exerts insulinotropic effects and inhibits gluconeogenesis in diabetic rats by regulating AMPK expression and PKCε concentration |
| Tomato | 📋 | | ⛔ | | 37215254 | Effects of tomato ketchup and tomato paste extract on hepatic lipid accumulation and adipogenesis |
| Vegetables | 📋 | | | | 38520525 | Fresh fruit, dried fruit, raw vegetables, and cooked vegetables consumption associated with progression trajectory of type 2 diabetes: a multi-state analysis of a prospective cohort |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 36500974 | Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats |
| Ashitaba | 📋 | ✍ | ⛔ | | 38557440 | Randomised, double-blind, parallel group comparison of Ashitaba (Angelica Keiskei) chalcone effects on visceral fat areas and waist circumference of overweight persons |
| Bay Leaf | 📋 | | ⛔ | | 38597184 | Antihyperlipidemic effect and GC-MS analysis of phytoconstituents from Laurus nobilis essential oil in rat |
| BCAA | 📋 | ✍ | ⛔ | | 37975111 | Association between type 2 diabetes and branched chain amino acids (BCAA); a case-control study |
| Carotenoids | 📋 | ✍ | ⛔ | | 38385583 | Effects of carotenoids on mitochondrial dysfunction |
| Carvacrol | 📋 | ✍ | ⛔ | | 38154959 | Carvacrol improves blood lipid and glucose in rats with type 2 diabetes mellitus by regulating short-chain fatty acids and the GPR41/43 pathway |
| Cordycepin | 📋 | | | | 37100012 | Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway |
| Coriander | 📋 | | ⛔ | | 37241925 | Coriander ( Coriandrum sativum) Polyphenols and Their Nutraceutical Value against Obesity and Metabolic Syndrome |
| Corn Silk | 📋 | ✍ | ⛔ | | 38132335 | Waste to Medicine: Evidence from Computational Studies on the Modulatory Role of Corn Silk on the Therapeutic Targets Implicated in Type 2 Diabetes Mellitus |
| Diosgenin | 📋 | | | | 36126194 | Therapeutic potential and research progress of diosgenin for lipid metabolism diseases |
| Eucommia | 📋 | ✍ | ⛔ | | 38518640 | Aqueous extract of fermented Eucommia ulmoides leaves alleviates hyperlipidemia by maintaining gut homeostasis and modulating metabolism in high-fat diet fed rats |
| Fennel | 📋 | ✍ | ⛔ | | 38678740 | Fennel seeds extract prevents fructose-induced cardiac dysfunction in a rat model of metabolic syndrome via targeting abdominal obesity, hyperuricemia and NF-κβ inflammatory pathway |
| Geniposide | 📋 | | | | 37107463 | Effective Therapeutic Verification of Crocin I, Geniposide, and Gardenia ( Gardenia jasminoides Ellis) on Type 2 Diabetes Mellitus In Vivo and In Vitro |
| Glycine | 📋 | ✍ | ⛔ | | 35052658 | GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study |
| HMB | 📋 | ✍ | ⛔ | | 37299513 | β-Hydroxy-β-methyl Butyrate Regulates the Lipid Metabolism, Mitochondrial Function, and Fat Browning of Adipocytes |
| Icariin | 📋 | ✍ | | | 38094047 | Icariin has the potential to induce the differentiation of bone marrow mesenchymal stem cells into brown fat cells via PDE5A inhibition |
| Iodine | 📋 | ✍ | ⛔ | | 38567251 | The correlation between iodine and metabolism: a review |
| Isoflavones | 📋 | ✍ | ⛔ | | 38569436 | Dietary isoflavone intake is inversely associated with remnant cholesterol in US adults: A cross-sectional study |
| Laminaria | 📋 | ✍ | ⛔ | | 38134985 | Laminaria japonica polysaccharide alleviates type 2 diabetes by regulating the microbiota-gut-liver axis: A multi-omics mechanistic analysis |
| Morin | 📋 | | | | 38091524 | Combination therapy of metformin and morin attenuates insulin resistance, inflammation, and oxidative stress in skeletal muscle of high-fat diet-fed mice |
| MUFA | 📋 | | ⛔ | | 38075228 | Monounsaturated and polyunsaturated fatty acids concerning prediabetes and type 2 diabetes mellitus risk among participants in the National Health and Nutrition Examination Surveys (NHANES) from 2005 to March 2020 |
| Noni | 📋 | | ⛔ | | 37794521 | Chronic supplementation of noni in diabetic type 1-STZ rats: effects on glycemic levels, kidney toxicity and exercise performance |
| Pectin | 📋 | ✍ | ⛔ | | 36756885 | Pectin mediates the mechanism of host blood glucose regulation through intestinal flora |
| Peony | 📋 | | ⛔ | | 37326061 | Paeonia lactiflora root decreases lipid accumulation through the induction of lipolysis and thermogenesis via AMPK activation in 3T3‑L1 cells |
| Poria Mushrooms | 📋 | ✍ | | | 38048892 | The anti-hyperlipidemic effects of Poria cocos (Schw.) Wolf extract: Modulating cholesterol homeostasis in hepatocytes via PPARα pathway |
| Rapamycin | 📋 | ✍ | | | 36674739 | Effect of Sirolimus/Metformin Co-Treatment on Hyperglycemia and Cellular Respiration in BALB/c Mice |
| Rapeseed Oil | 📋 | ✍ | | | 37740067 | Effects of rapeseed oil on body composition and glucolipid metabolism in people with obesity and overweight: a systematic review and meta-analysis |
| Rhodiola | 📋 | ✍ | ⛔ | | 37457904 | Effect of Rhodiola rosea Rhizome and Punica granatum Fruit Peel on the Metabolic Processes and Physiological Activity of Rats Fed with Excessively Fat Diet |
| Spices | 📋 | | | | 38542668 | Effect of Aromatic Herbs and Spices Present in the Mediterranean Diet on the Glycemic Profile in Type 2 Diabetes Subjects: A Systematic Review and Meta-Analysis |
| Stigmasterol | 📋 | | | | 31759199 | Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine |
| Trans-Resveratrol | 📋 | | | | 34999386 | Comprehensive assessment of the effectiveness of l-carnitine and transresveratrol in rats with diet-induced obesity |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 37485499 | Ursolic acid ameliorates obesity of mice fed with high-fat diet via alteration of gut microbiota and amino acid metabolism |
| Wine | 📋 | | ⛔ | | 37254366 | Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota |
| Wogonin | 📋 | ✍ | ⛔ | | 36235573 | Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4-FGF21 Signaling in Mouse Hepatocyte AML12 Cells |
| Anethole | 📋 | | | | 37457161 | Cookies enriched with anethole and secoisolariciresinol diglucoside from flaxseed and fennel seeds improve hypercholesterolemia, lipid profile, and liver functions: A pilot study |
| Banana | 📋 | | ⛔ | | 35852116 | Unripe banana flour (Musa cavendishii) promotes increased hypothalamic antioxidant activity, reduced caloric intake, and abdominal fat accumulation in rats on a high-fat diet |
| Bromelain | 📋 | ✍ | ⛔ | | 37749825 | Protective effect of bromelain on some metabolic enzyme activities in tyloxapol-induced hyperlipidemic rats |
| Chitosan | 📋 | ✍ | ⛔ | | 36064382 | The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial |
| Clove | 📋 | | ⛔ | | 34856360 | Exercise and Syzygium aromaticum reverse memory deficits, apoptosis and mitochondrial dysfunction of the hippocampus in Alzheimer's disease |
| Cornus | 📋 | | | | 35684107 | Cornus mas L. Increases Glucose Uptake and the Expression of PPARG in Insulin-Resistant Adipocytes |
| Creatine | 📋 | ✍ | ⛔ | | 36773834 | Creatine ameliorates high-fat diet-induced obesity by regulation of lipolysis and lipophagy in brown adipose tissue and liver |
| Diallyl Trisulfide | 📋 | | | | 38185348 | Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210 |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 32594769 | The Effect of Evening Primrose Oil ( Oenothera biennis) on the Level of Adiponectin and Some Biochemical Parameters in Rats With Fructose Induced Metabolic Syndrome |
| Fish Collagen | 📋 | ✍ | ⛔ | | 37367668 | Fish-Derived Protein Hydrolysates Increase Insulin Sensitivity and Alter Intestinal Microbiome in High-Fat-Induced Obese Mice |
| Fruits | 📋 | | | | 38520525 | Fresh fruit, dried fruit, raw vegetables, and cooked vegetables consumption associated with progression trajectory of type 2 diabetes: a multi-state analysis of a prospective cohort |
| Glabridin | 📋 | | | | 23426874 | Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus |
| Glucosamine | 📋 | ✍ | ⛔ | | 37329549 | Glucosamine effects on platelet aggregation of type 2 diabetes mellitus patients: in vitro assays |
| Goat Milk | 📋 | | ⛔ | | 37990402 | Goat Milk Improves Glucose Metabolism in Type 2 Diabetic Mice and Protects Pancreatic β-Cell Functions |
| Gotu Kola | 📋 | ✍ | ⛔ | | 32526339 | Lei-gong-gen formula granule attenuates hyperlipidemia in rats via cGMP-PKG signaling pathway |
| Grapefruit Essential Oil | 📋 | ✍ | ⛔ | | 32760938 | Dietary citrus peel essential oil ameliorates hypercholesterolemia and hepatic steatosis by modulating lipid and cholesterol homeostasis |
| Honeysuckle | 📋 | | ⛔ | | 36313074 | Lonicerae Japonicae Flos extract and chlorogenic acid attenuates high-fat-diet- induced prediabetes via CTRPs-AdipoRs-AMPK/PPARα axes |
| Isoquercitrin | 📋 | | | | 36205648 | Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo |
| Lavender | 📋 | ✍ | ⛔ | | 37850338 | Lavandula angustifolia mill. (Lamiaceae) ethanol extract and its main constituents as promising agents for the treatment of metabolic disorders: chemical profile, in vitro biological studies, and molecular docking |
| Licochalcones | 📋 | | | | 31083505 | Protective Effects of Licochalcone A Ameliorates Obesity and Non-Alcoholic Fatty Liver Disease Via Promotion of the Sirt-1/AMPK Pathway in Mice Fed a High-Fat Diet |
| Maca Root | 📋 | ✍ | ⛔ | | 38056538 | Maca roots: A potential therapeutic in the management of metabolic disorders through the modulation of metabolic biochemical markers in rats fed high-fat high-carbohydrate diet |
| Mushrooms | 📋 | | ⛔ | | 38228086 | A prospective association between dietary mushroom intake and the risk of type 2 diabetes: the Korean Genome and Epidemiology Study-Cardiovascular Disease Association Study |
| Oregano | 📋 | ✍ | ⛔ | | 35720461 | Metabolites of oregano ( Origanum vulgare) seed and their anti-obesity effects on 3T3-L1 adipocytes through down-regulated adipogenesis |
| Oyster Mushrooms | 📋 | | ⛔ | | 38609215 | Dietary intake of whole king oyster mushroom (Pleurotus eryngii) attenuated obesity via ameliorating lipid metabolism and alleviating gut microbiota dysbiosis |
| Perilla | 📋 | ✍ | | | 37160801 | Perilla, sunflower, and tea seed oils as potential dietary supplements with anti-obesity effects by modulating the gut microbiota composition in mice fed a high-fat diet |
| Pineapple | 📋 | ✍ | ⛔ | | 36062986 | Pineapple fruit improves vascular endothelial dysfunction, hepatic steatosis, and cholesterol metabolism in rats fed a high-cholesterol diet |
| Potato | 📋 | | ⛔ | | 36117546 | Potato consumption is not associated with cardiometabolic health outcomes in Framingham Offspring Study adults |
| Rosehip | 📋 | ✍ | ⛔ | | 38332573 | The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice |
| Schisandrins | 📋 | | | | 36200699 | Schisandrin C isolated from Schisandra chinensis fruits inhibits lipid accumulation by regulating adipogenesis and lipolysis through AMPK signaling in 3T3-L1 adipocytes |
| Tea Polyphenols | 📋 | | | | 36444016 | Tea polyphenol and epigallocatechin gallate ameliorate hyperlipidemia via regulating liver metabolism and remodeling gut microbiota |
| UDCA | 📋 | ✍ | ⛔ | | 38578526 | Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 34407851 | Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis |
| Vitamin K | 📋 | ✍ | ⛔ | | 37724446 | The relationship between vitamin K and T2DM: a systematic review and meta-analysis |
| Vitamin K1 | 📋 | ✍ | ⛔ | | 30352877 | Circulating Phylloquinone Concentrations and Risk of Type 2 Diabetes: A Mendelian Randomization Study |
| Zingerone | 📋 | | | | 36424723 | Modulation of PPARα-Thermogenesis-Gut Microbiota Interactions in Obese Mice Administrated with Zingerone |
| Anthocyanidins | 📋 | | | | 36436987 | Anthocyanins and Curcumin: Possible Abilities of Prevention of Diabetes and Obesity via Stimulation of Glucagon-Like Peptide-1 Secretion and Induction of Beige Adipocyte Formation |
| Artemisinin | 📋 | | | | 38382280 | Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway |
| Balloon Flower | 📋 | ✍ | ⛔ | | 38674532 | Revealing Molecular Mechanisms of the Bioactive Saponins from Edible Root of Platycodon grandiflorum in Combating Obesity |
| Bamboo | 📋 | ✍ | ⛔ | | 37048203 | Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism |
| Betulinic Acid | 📋 | | | | 36242845 | Betulinic acid counteracts the lipid accumulation in Caenorhabditis elegans by modulation of nhr-49 expression |
| Bile Salts | 📋 | | | | 38180064 | Bile salt signaling and bile salt-based therapies in cardiometabolic disease |
| Bilobalide | 📋 | | | | 37687239 | Bilobalide Induces Apoptosis in 3T3-L1 Mature Adipocytes through ROS-Mediated Mitochondria Pathway |
| Biochanin A | 📋 | | | | 36379122 | Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2/System xc-/GPX4 axis |
| Bitter Orange | 📋 | ✍ | ⛔ | | 38219880 | Flavonoid extracts of Citrus aurantium L. var. amara Engl. Promote browning of white adipose tissue in high-fat diet-induced mice |
| Black Ginger | 📋 | ✍ | ⛔ | | 38194854 | A systematic review and meta-analysis of animal and human studies demonstrates the beneficial effects of Kaempferia parviflora on metabolic syndrome and erectile dysfunction |
| Bladderwrack | 📋 | ✍ | ⛔ | | 38667804 | Exploring the Hypocholesterolemic Potential of a Fucus vesiculosus Extract: Omic Insights into Molecular Mechanisms at the Intestinal Level |
| Calcium | 📋 | ✍ | ⛔ | | 32497284 | The Functional Nutritional and Regulatory Activities of Calcium Supplementation From Eggshell for Obesity Disorders Management |
| Casein Protein | 📋 | ✍ | ⛔ | | 37798798 | Effects of supplementation with milk protein on glycemic parameters: a GRADE-assessed systematic review and dose-response meta-analysis |
| Cashew | 📋 | | ⛔ | | 36358575 | Anxiety, Insomnia, and Memory Impairment in Metabolic Syndrome Rats Are Alleviated by the Novel Functional Ingredients from Anacardium occidentale |
| Cheese | 📋 | | ⛔ | | 36333201 | Association of dairy consumption patterns with the incidence of type 2 diabetes: Findings from Alberta's Tomorrow Project |
| Chondroitin | 📋 | ✍ | ⛔ | | 37294270 | Chondroitin Sulfate Alleviated Obesity by Modulating Gut Microbiota and Liver Metabolome in High-Fat-Diet-Induced Obese Mice |
| Citicoline | 📋 | ✍ | ⛔ | | 34715589 | Choline or CDP-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally - Induced endotoxic shock |
| Citrus Fruits | 📋 | | ⛔ | | 37702528 | Roles of citrus fruits on energy expenditure, body weight management, and metabolic biomarkers: a comprehensive review |
| Corn | 📋 | | ⛔ | | 35485907 | Black corn ( Zea mays L.) whole flour improved the antioxidant capacity and prevented adipogenesis in mice fed a high-fat diet |
| Coumaric acid | 📋 | | | | 37033655 | Caryopteris odorata and its metabolite coumarin attenuate characteristic features of cardiometabolic syndrome in high-refined carbohydrate-high fat-cholesterol-loaded feed-fed diet rats |
| Echinacea | 📋 | ✍ | ⛔ | | 28061036 | Antioxidant, Antidiabetic, and Antihypertensive Properties of Echinacea Purpurea Flower Extract and Caffeic Acid Derivatives Using In Vitro Models |
| Escin | 📋 | ✍ | ⛔ | | 36394728 | Anti-obesity effect of escin: a study on high-fat diet-induced obese mice |
| Essential Amino Acids | 📋 | ✍ | ⛔ | | 37397466 | A balanced formula of essential amino acids promotes brain mitochondrial biogenesis and protects neurons from ischemic insult |
| Essential Fatty Acids | 📋 | ✍ | | | 32919185 | ω-6/ω-3 fatty acid ratio as an essential predictive biomarker in the management of type 2 diabetes mellitus |
| Fermented Foods | 📋 | | ⛔ | | 37862057 | Soy Sauce Lowers Body Weight and Fat Mass in High-Fat Diet-Induced Obese Rats |
| Formononetin | 📋 | | | | 38070245 | Formononetin ameliorates isoproterenol induced cardiac fibrosis through improving mitochondrial dysfunction |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 34281337 | γ-Linolenic Acid Prevents Lipid Metabolism Disorder in Palmitic Acid-Treated Alpha Mouse Liver-12 Cells by Balancing Autophagy and Apoptosis via the LKB1-AMPK-mTOR Pathway |
| Gymnema Sylvestre | 📋 | ✍ | ⛔ | | 37110174 | Gymnema Sylvestre Supplementation Restores Normoglycemia, Corrects Dyslipidemia, and Transcriptionally Modulates Pancreatic and Hepatic Gene Expression in Alloxan-Induced Hyperglycemic Rats |
| Haskap | 📋 | | | | 34679767 | Anti-Sarcopenic Obesity Effects of Lonicera caerulea Extract in High-Fat Diet-Fed Mice |
| Hyperoside | 📋 | | | | 37128768 | Hyperoside inhibits pancreatic lipase activity in vitro and reduces fat accumulation in vivo |
| Jujube | 📋 | | ⛔ | | 38308575 | Untargeted metabolomics analysis of probiotic jujube juice and its anti-obesity effects on the high-fat diet-induced obese mice |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 37551550 | Labisia pumila standardized extract (SKF7®) reduces percentage of waist circumference and waist-to-height ratio in individuals with obesity |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 35088560 | Dietary tryptophan and the risk of obesity and type 2 diabetes: Total effect and mediation effect of sleep duration |
| Lemon Balm Essential Oil | 📋 | ✍ | ⛔ | | 22279139 | Melissa officinalis essential oil reduces plasma triglycerides in human apolipoprotein E2 transgenic mice by inhibiting sterol regulatory element-binding protein-1c-dependent fatty acid synthesis |
| Lupeol | 📋 | | | | 37842512 | Lupeol attenuated the NAFLD and PCOS-induced metabolic, oxidative, hormonal, histopathological, and molecular injuries in mice |
| Lychee | 📋 | | ⛔ | | 35179169 | Litchi chinensis seed prevents obesity and modulates the gut microbiota and mycobiota compositions in high-fat diet-induced obese zebrafish |
| Matcha Tea | 📋 | | | | 35921023 | A Prospective Non-Randomized Open-Label Comparative Study of The Effects of Matcha Tea on Overweight and Obese Individuals: A Pilot Observational Study |
| Millet | 📋 | | | | 36444094 | Effects of heat-treated starch and protein from foxtail millet (Setaria italica) on type 2 diabetic mice |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 29361517 | Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity |
| Patchouli | 📋 | ✍ | ⛔ | | 36314728 | Pogostone attenuates adipose tissue inflammation by regulating the adipocyte-macrophage crosstalk via activating SIRT1 |
| Peach | 📋 | | ⛔ | | 33158191 | Anti-Obesity Effects of a Prunus persica and Nelumbo nucifera Mixture in Mice Fed a High-Fat Diet |
| Pear | 📋 | | ⛔ | | 31034714 | Pear Extract and Malaxinic Acid Reverse Obesity, Adipose Tissue Inflammation, and Hepatosteatosis in Mice |
| Pecan | 📋 | | ⛔ | | 37299553 | Pecans and Its Polyphenols Prevent Obesity, Hepatic Steatosis and Diabetes by Reducing Dysbiosis, Inflammation, and Increasing Energy Expenditure in Mice Fed a High-Fat Diet |
| Phosphatidylcholine | 📋 | ✍ | ⛔ | | 36363476 | Protective Effects of Phosphatidylcholine against Hepatic and Renal Cell Injury from Advanced Glycation End Products |
| Phytosterols | 📋 | | | | 37960208 | The Effect of Dietary Supplementation with Plant Sterols on Total and LDL-Cholesterol in Plasma Is Affected by Adherence to Mediterranean Diet: Insights from the DESCO Randomized Clinical Study |
| Postbiotics | 📋 | | | | 38474810 | Nutritional Approaches Targeting Gut Microbiota in Oxidative-Stress-Associated Metabolic Syndrome: Focus on Early Life Programming |
| Rye | 📋 | | ⛔ | | 37898434 | Effects of Wholegrain Compared to Refined Grain Intake on Cardiometabolic Risk Markers, Gut Microbiota and Gastrointestinal Symptoms in Children: A Randomized Crossover Trial |
| Sage Essential Oil | 📋 | | ⛔ | | 37013759 | Studying the actions of sage and thymoquinone combination on metabolic syndrome induced by high-fat diet in rats |
| Salt | 📋 | | ⛔ | | 37675565 | Sodium as an Important Regulator of Immunometabolism |
| Sardine | 📋 | | ⛔ | | 36860672 | Cardiovascular and lipid-lowering effects of a marine lipoprotein extract in a high-fat diet-induced obesity mouse model |
| Scutellarin | 📋 | | | | 38094008 | Scutellarin alleviates liver injury in type 2 diabetic mellitus by suppressing hepatocyte apoptosis in vitro and in vivo |
| Sesame Oil | 📋 | | ⛔ | | 35685535 | Sesame Oil Ameliorates Alanine Aminotransferase, Aspartate Aminotransferase, and Fatty Liver Grade in Women with Nonalcoholic Fatty Liver Disease Undergoing Low-Calorie Diet: A Randomized Double-Blind Controlled Trial |
| Shogaol | 📋 | | | | 36766032 | Effects of 6-Shogaol on Glucose Uptake and Intestinal Barrier Integrity in Caco-2 Cells |
| Star Anise | 📋 | ✍ | ⛔ | | 36421427 | Antioxidant, Anti-Obesity, and Hypolipidemic Effects of Polyphenol Rich Star Anise ( Illicium verum) Tea in High-Fat-Sugar Diet-Induced Obesity Rat Model |
| Tannic Acid | 📋 | ✍ | ⛔ | | 37525894 | Tannic Acid Ameliorates Systemic Glucose and Lipid Metabolic Impairment Induced by Low-Dose T-2 Toxin Exposure |
| Theobromine | 📋 | ✍ | ⛔ | | 37615657 | Theobromine supplementation in combination with a low-calorie diet improves cardiovascular risk factors in overweight and obese subjects with metabolic syndrome: a randomized controlled trial |
| Thyme | 📋 | ✍ | ⛔ | | 38068865 | Thyme Extract Alleviates High-Fat Diet-Induced Obesity and Gut Dysfunction |
| Thymol | 📋 | ✍ | ⛔ | | 34401075 | Inverse molecular docking reveals a novel function of thymol: Inhibition of fat deposition induced by high-dose glucose in Caenorhabditis elegans |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 36047096 | Dietary High-Dose Biotin Intake Activates Fat Oxidation and Hepatic Carnitine Palmitoyltransferase in Rat |
| White Mushrooms | 📋 | | ⛔ | | 38472823 | Exploring Therapeutic Potential of Pleurotus ostreatus and Agaricus bisporus Mushrooms against Hyperlipidemia and Oxidative Stress Using Animal Model |
| Activated Charcoal | 📋 | ✍ | ⛔ | | 37842254 | Dietary Bamboo Charcoal Decreased Visceral Adipose Tissue Weight by Enhancing Fecal Lipid Excretions in Mice with High-Fat Diet-Induced Obesity |
| Alfalfa | 📋 | | ⛔ | | 38387635 | Microbiological and metabolic pathways analysing the mechanisms of alfalfa polysaccharide and sulfated alfalfa polysaccharide in alleviating obesity |
| Almond Oil | 📋 | | ⛔ | | 31428332 | Co-ingestion of whole almonds and almond oil with carbohydrate suppresses postprandial glycaemia in mice in an insulin-dependent and insulin-independent manner |
| Aloe-Emodin | 📋 | | | | 38286356 | Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action |
| Amino Acids | 📋 | | | | 37755297 | Unlocking the Potential: Amino Acids' Role in Predicting and Exploring Therapeutic Avenues for Type 2 Diabetes Mellitus |
| Asparagus | 📋 | | ⛔ | | 36313282 | Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice |
| Aspirin | 📋 | | ⛔ | | 38142708 | Daily low-dose aspirin and incident type 2 diabetes in community-dwelling healthy older adults: a post-hoc analysis of efficacy and safety in the ASPREE randomised placebo-controlled trial |
| Astragalin | 📋 | | | | 32216601 | Astragalin, (3-O-glucoside of kaempferol), isolated from Moringa oleifera leaves modulates leptin, adiponectin secretion and inhibits adipogenesis in 3T3-L1 adipocytes |
| Atractylodes | 📋 | ✍ | ⛔ | | 38560167 | The anti-hyperlipidemia effect of Atractylodes macrocephala Rhizome increased HDL via reverse cholesterol transfer |
| Bean | 📋 | | ⛔ | | 37960148 | Minimal Effective Dose of Beans Required to Elicit a Significantly Lower Glycemic Response Than Commonly Consumed Starchy Foods: Predictions Based on In Vitro Digestion and Carbohydrate Analysis |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 35121344 | Anti-diabetic potential of β-boswellic acid and 11-keto-β-boswellic acid: Mechanistic insights from computational and biochemical approaches |
| Calycosin | 📋 | | | | 36195188 | Calycosin ameliorates advanced glycation end product-induced neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease |
| Cantaloupe | 📋 | | ⛔ | | 37571229 | Adiposity Reduction by Cucumis melo var. gaettongchamoe Extract in High-Fat Diet-Induced Obese Mice |
| Cardamonin | 📋 | | | | 37612419 | Cardamonin protects against iron overload induced arthritis by attenuating ROS production and NLRP3 inflammasome activation via the SIRT1/p38MAPK signaling pathway |
| Cat's Claw | 📋 | ✍ | ⛔ | | 37968654 | Effect of Uncaria tomentosa aqueous extract on the response to palmitate-induced lipotoxicity in cultured skeletal muscle cells |
| Celery | 📋 | | ⛔ | | 34606532 | Beneficial impacts of fermented celery ( Apium graveolens L.) juice on obesity prevention and gut microbiota modulation in high-fat diet fed mice |
| Chickpea | 📋 | | ⛔ | | 37977304 | Integrating serum pharmacochemistry and network pharmacology to reveal the mechanism of chickpea in improving insulin resistance |
| Chicory | 📋 | ✍ | ⛔ | | 35228184 | A randomized controlled trial on albino rats treated with chicory plant to improve liver efficiency |
| Cumin | 📋 | | ⛔ | | 38004077 | In Vitro Assessment of Anti-Adipogenic and Anti-Inflammatory Properties of Black Cumin ( Nigella sativa L.) Seeds Extract on 3T3-L1 Adipocytes and Raw264.7 Macrophages |
| Delphinidin | 📋 | | | | 38387526 | Anthocyanins and their metabolites promote white adipose tissue beiging by regulating mitochondria thermogenesis and dynamics |
| Essential Oils | 📋 | | ⛔ | | 38003691 | Antioxidant and Hypoglycemic Potential of Essential Oils in Diabetes Mellitus and Its Complications |
| Fish | 📋 | | ⛔ | | 38263170 | Dietary patterns derived by reduced rank regression are associated with lipid disorders among Korean adults: a cross-sectional analysis |
| Genipin | 📋 | | | | 38727186 | Genipin improves obesity through promoting bile secretion and changing bile acids composition in diet-induced obese rats |
| Geraniol | 📋 | | | | 38052812 | Geraniol reverses obesity by improving conversion of WAT to BAT in high fat diet induced obese rats by inhibiting HMGCoA reductase |
| Giloy | 📋 | ✍ | ⛔ | | 37579290 | Neuroprotective Effects of Tinospora cordifolia via Reducing the Oxidative Stress and Mitochondrial Dysfunction against Rotenone-Induced PD Mice |
| Guggulsterone | 📋 | | | | 38089157 | Effect of dietary supplementation with a new nutraceutical formulation on cardiometabolic risk factors: a double-blind, placebo-controlled, randomized clinical study |
| Hypericin | 📋 | | | | 37183545 | Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning |
| L-Alanine | 📋 | ✍ | ⛔ | | 36125865 | Coadministration of L-alanine and L-glutamine ameliorate blood glucose levels, biochemical indices and histological features in alloxan-induced diabetic rats |
| Lentil | 📋 | | ⛔ | | 38337705 | Twelve Weeks of Daily Lentil Consumption Improves Fasting Cholesterol and Postprandial Glucose and Inflammatory Responses-A Randomized Clinical Trial |
| Ligustilide | 📋 | | | | 32643505 | Ligustilide alleviates the insulin resistance, lipid accumulation, and pathological injury with elevated phosphorylated AMPK level in rats with diabetes mellitus |
| Magnolia | 📋 | ✍ | ⛔ | | 36067838 | Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221 |
| Magnolol | 📋 | | | | 35215317 | Magnolol and Luteolin Inhibition of α-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies |
| Minerals | 📋 | | | | 37887373 | The Link between Trace Metal Elements and Glucose Metabolism: Evidence from Zinc, Copper, Iron, and Manganese-Mediated Metabolic Regulation |
| PEA | 📋 | ✍ | ⛔ | | 37599675 | Palmitoylethanolamide counteracts high-fat diet-induced gut dysfunction by reprogramming microbiota composition and affecting tryptophan metabolism |
| Pine Nut | 📋 | | ⛔ | | 36156349 | Pine nut oil supplementation alleviates the obesogenic effects in high-fat diet induced obese rats: A comparative study between epididymal and retroperitoneal adipose tissue |
| Potassium | 📋 | ✍ | ⛔ | | 38049705 | Dietary Potassium and Magnesium Intake with Risk of Type 2 Diabetes Mellitus Among Rural China: the Henan Rural Cohort Study |
| Pregnenolone | 📋 | ✍ | ⛔ | | 35108514 | Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders |
| Protein | 📋 | ✍ | ⛔ | | 37972527 | High-protein diet with excess leucine prevents inactivity-induced insulin resistance in women |
| Red Clover | 📋 | ✍ | ⛔ | | 33761143 | Effects of isoflavone-rich red clover extract on blood glucose level: A randomized, double-blind, placebo-controlled trial |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 31353725 | Ameliorative impact of cold-pressed Rosmarinus officinalis oil against liver toxicity and genotoxic effects in streptozotocin-induced diabetic rats and their offspring |
| Safflower | 📋 | ✍ | ⛔ | | 34487844 | Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity, blood pressure, and insulin resistance in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled clinical trial |
| Safranal | 📋 | | | | 35551973 | Inhibitory effect of saffron, crocin, crocetin, and safranal against adipocyte differentiation in human adipose-derived stem cells |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 34161166 | Standardized Saw Palmetto Extract Directly and Indirectly Affects Testosterone Biosynthesis and Spermatogenesis |
| Senolytics | 📋 | | | | 37317964 | Increased cell senescence in human metabolic disorders |
| Sunflower | 📋 | | ⛔ | | 38217909 | Sunflower seed extract supplementation reduces body fat in adults with obesity: A double-blind, randomized, placebo-controlled trial |
| Vitamin B Complex | 📋 | | ⛔ | | 37637782 | The Effects of Vitamin B-Complex Supplementation on Serum Homocysteine Levels and Migraine Severity in Children A Randomized Controlled Trial |
| Vitexin | 📋 | | | | 35320011 | Suppression of Adipogenesis and Fat Accumulation by Vitexin Through Activation of Hedgehog Signaling in 3T3-L1 Adipocytes |
| Wasabi | 📋 | | ⛔ | | 36360048 | Wasabi ( Eutrema japonicum) Reduces Obesity and Blood Pressure in Diet-Induced Metabolic Syndrome in Rats |
| Wheat | 📋 | | ⛔ | | 35408659 | The Hypolipidemic and Antioxidant Activity of Wheat Germ and Wheat Germ Protein in High-Fat Diet-Induced Rats |
| Yam | 📋 | | | | 38613011 | A Comparative Analysis between Whole Chinese Yam and Peeled Chinese Yam: Their Hypolipidemic Effects via Modulation of Gut Microbiome in High-Fat Diet-Fed Mice |
| Anise | 📋 | ✍ | ⛔ | | 31724151 | Aqueous anise extract alleviated the pancreatic changes in streptozotocin-induced diabetic rat model via modulation of hyperglycaemia, oxidative stress, apoptosis and autophagy: a biochemical, histological and immunohistochemical study |
| Arctiin | 📋 | | | | 37800616 | Arctiin attenuates iron overload‑induced osteoporosis by regulating the PI3K/Akt pathway |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 38380214 | Analyzing the Antihyperglycemic Effect of Cissus quadrangularis and Bacopa monnieri on 3T3-L1 Cell Lines |
| Bee Venom | 📋 | ✍ | ⛔ | | 37274913 | Metformin and Bee Venom: a Comparative Detection of Histological Alteration of the Pancreas and Systemic Inflammatory Markers in Diabetic Mice |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 30501605 | Hypoglycemic and Hypolipemic Effects of a New Lecithin Formulation of Bergamot Polyphenolic Fraction: A Double Blind, Randomized, Placebo- Controlled Study |
| Beta-Alanine | 📋 | ✍ | ⛔ | | 36513312 | Oat β-Glucan Ameliorates Diabetes in High Fat Diet and Streptozotocin-induced Mice by Regulating Metabolites |
| Cabbage | 📋 | | ⛔ | | 36866218 | The protective effect of red cabbage on water-soluble fractions of spent crankcase oil-induced alterations in lipid function biomarkers and atherogenic indices in male Albino rats |
| Capsanthin | 📋 | | | | 35910274 | Comparison of the Anti-Obesity Effect of Enriched Capsanthin and Capsaicin from Capsicum annuum L. Fruit in Obesity-Induced C57BL/6J Mouse Model |
| Chili Pepper | 📋 | | ⛔ | | 36907948 | Enhanced hypoglycemic bioactivity via RAS/Raf-1/MEK/ERK signaling pathway by combining capsaicin and QUERCETIN from chili peppers |
| Clove Essential Oil | 📋 | | ⛔ | | 35212917 | Syzygium aromaticum bud (clove) essential oil is a novel and safe aldose reductase inhibitor: in silico, in vitro, and in vivo evidence |
| Coconut Protein | 📋 | | | | 15274481 | Influence of Coconut Kernel Protein on Lipid Metabolism in Alcohol Fed Rats |
| Copper | 📋 | ✍ | ⛔ | | 35178418 | Associations of the Dietary Iron, Copper, and Selenium Level With Metabolic Syndrome: A Meta-Analysis of Observational Studies |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 35326092 | Coriander Oil Reverses Dexamethasone-Induced Insulin Resistance in Rats |
| Costus | 📋 | ✍ | ⛔ | | 33069202 | The anti-diabetic effect of some plant extracts against Streptozotocin - induced diabetes type 2 in male albino rats |
| D-Limonene | 📋 | ✍ | ⛔ | | 36678138 | D-Limonene Promotes Anti-Obesity in 3T3-L1 Adipocytes and High-Calorie Diet-Induced Obese Rats by Activating the AMPK Signaling Pathway |
| D-Ribose | 📋 | ✍ | ⛔ | | 35684021 | A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD + Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial |
| Diallyl Disulfide | 📋 | | | | 38042045 | Effects of diallyl disulfide administration on insulin resistance in high-fat diet-fed mice |
| Dill | 📋 | | ⛔ | | 38304787 | Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses |
| Echinacoside | 📋 | | | | 38215960 | Echinacoside stimulates myogenesis and ATP-dependent thermogenesis in the skeletal muscle via the activation of D1-like dopaminergic receptors |
| Eclipta Alba | 📋 | ✍ | | | 34785414 | Phytochemical wedelolactone reverses obesity by prompting adipose browning through SIRT1/AMPK/ PPARα pathway via targeting nicotinamide N-methyltransferase |
| Eggplant | 📋 | | ⛔ | | 38030047 | Solanum melongena extract supplementation protected skeletal muscle and brain damage by regulation of BDNF/PGC1α/irisin pathway via brain function-related myokines in high-fat diet induced obese mice |
| Eleuthero | 📋 | ✍ | ⛔ | | 37467688 | Syringin alleviates hepatic fibrosis by enhancing autophagic flux and attenuating ER stress-TRIB3/SMAD3 in diabetic mice |
| Eucalyptus | 📋 | ✍ | ⛔ | | 36005629 | Insulin Secretory Actions of Ethanol Extract of Eucalyptus citriodora Leaf, including Plasma DPP-IV and GLP-1 Levels in High-Fat-Fed Rats, as Well as Characterization of Biologically Effective Phytoconstituents |
| Flavones | 📋 | | | | 36555392 | Anti-Inflammatory Mechanisms of Dietary Flavones: Tapping into Nature to Control Chronic Inflammation in Obesity and Cancer |
| Garlic Oil | 📋 | | ⛔ | | 35959265 | Garlic oil alleviates high triglyceride levels in alcohol-exposed rats by inhibiting liver oxidative stress and regulating the intestinal barrier and intestinal flora |
| Geraniin | 📋 | | | | 36706894 | Geraniin targeting CaMKK2 inhibits lipid accumulation in 3T3-L1 adipocytes by suppressing lipogenesis |
| Geranium | 📋 | | | | 35170422 | Effect of Pelargonium graveolens on Glucose Metabolism in Streptozotocin-Induced Diabetic Rats |
| Ginkgetin | 📋 | | | | 30472463 | Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation |
| Glycyrrhetinic Acid | 📋 | | | | 38346790 | Natural Sweetener Glycyrrhetinic Acid Monoglucuronide Improves Glucose Homeostasis in Healthy Mice |
| Grape Seed Oil | 📋 | | ⛔ | | 31117552 | Hypocholesterolemic Effects of Expeller-Pressed and Solvent-Extracted Fruit Seed Oils and Defatted Pomegranate Seed Meals |
| Grapefruit | 📋 | | ⛔ | | 27134462 | Antihyperlipidemic effects of Citrus sinensis, Citrus paradisi, and their combinations |
| Hops | 📋 | ✍ | ⛔ | | 36074228 | Humulus lupulus L. extract and its active constituent xanthohumol attenuate oxidative stress and nerve injury induced by iron overload via activating AKT/GSK3β and Nrf2/NQO1 pathways |
| Indian Barberry | 📋 | ✍ | ⛔ | | 33040642 | The effects of Berberis vulgaris L. and Berberis aristata L. in metabolic syndrome patients: a systematic and meta-analysis study |
| Kimchi | 📋 | | ⛔ | | 36752575 | Effect of kimchi intake on body weight of general community dwellers: a prospective cohort study |
| Lemongrass Essential Oil | 📋 | ✍ | ⛔ | | 34981531 | Lemongrass essential oil and its major constituent citral isomers modulate adipogenic gene expression in 3T3-L1 cells |
| Lettuce | 📋 | | ⛔ | | 34261489 | The acute effect of incorporating lettuce or watercress into a moderately high-fat meal on postprandial lipid, glycemic response, and plasma inflammatory cytokines in healthy young men: a randomized crossover trial |
| Limonin | 📋 | | | | 36857910 | Limonin mitigates cardiometabolic complications in rats with metabolic syndrome through regulation of the IRS-1/GLUT4 signalling pathway |
| Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 37270132 | Structural characterization of Hericium erinaceus polysaccharides and the mechanism of anti-T2DM by modulating the gut microbiota and metabolites |
| Liquiritigenin | 📋 | | | | 35334944 | Liquiritigenin Inhibits Lipid Accumulation in 3T3-L1 Cells via mTOR-Mediated Regulation of the Autophagy Mechanism |
| Madecassoside | 📋 | | | | 38588466 | Madecassoside modulates lipid metabolism in visceral adipocytes: exploring the browning, lipolysis, and lipogenesis mechanisms for potential obesity treatment |
| Mandarin | 📋 | | | | 38674060 | Narirutin-Rich Celluclast Extract from Mandarin (Citrus unshiu) Peel Alleviates High-Fat Diet-Induced Obesity and Promotes Energy Metabolism in C57BL/6 Mice |
| Marjoram | 📋 | | ⛔ | | 35036595 | Optimization of ultrasonic-assisted extraction of polyphenols from the polyherbal formulation of Cinnamomum verum, Origanum majorana, and Origanum vulgare and their anti-diabetic capacity in zebrafish ( Danio rerio) |
| Mastic | 📋 | ✍ | ⛔ | | 35691258 | Efficacy of a standardized herbal product from Pistacia atlantica subsp. Kurdica in type 2 diabetic patients with hyperlipidemia: A triple-blind randomized clinical trial |
| Myrtle | 📋 | ✍ | ⛔ | | 34388525 | Effect of supplementation of Rhodomyrtus tomentosa fruit juice in preventing hypercholesterolemia and atherosclerosis development in rats fed with high fat high cholesterol diet |
| Myrtle Essential Oil | 📋 | ✍ | ⛔ | | 15234770 | Hypoglycaemic effects of myrtle oil in normal and alloxan-diabetic rabbits |
| Neohesperidin | 📋 | | | | 35862634 | Neohesperidin Dihydrochalcone Ameliorates High-Fat Diet-Induced Glycolipid Metabolism Disorder in Rats |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 33933722 | Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study |
| Parthenolide | 📋 | | | | 36234807 | First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor |
| Pau d'Arco | 📋 | ✍ | ⛔ | | 27539320 | The anti-obesity effect of Taheebo (Tabebuia avellanedae Lorentz ex Griseb) extract in ovariectomized mice and the identification of a potential anti-obesity compound |
| Pelargonidin | 📋 | | | | 31696323 | Pelargonidin 3-glucoside-enriched Strawberry Attenuates Symptoms of DSS-induced Inflammatory Bowel Disease and Diet-Induced Metabolic Syndrome in Rats |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 28922713 | Peppermint essential oil alleviates hyperglycemia caused by streptozotocin- nicotinamide-induced type 2 diabetes in rats |
| Pomelo | 📋 | | ⛔ | | 26966424 | The protective effects of pomelo extract (Citrus grandis L. Osbeck) against fructose-mediated protein oxidation and glycation |
| Pumpkin Seed Oil | 📋 | ✍ | ⛔ | | 29553847 | Reversal of high fat diet-induced obesity through modulating lipid metabolic enzymes and inflammatory markers expressions in rats |
| Radish | 📋 | | ⛔ | | 35686604 | A water soluble extract of radish greens ameliorates high fat diet-induced obesity in mice and inhibits adipogenesis in preadipocytes |
| Retinoic Acid | 📋 | | | | 28507012 | Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis |
| SAMe | 📋 | ✍ | ⛔ | | 35893906 | Effects of Amino Acids Supplementation on Lipid and Glucose Metabolism in HepG2 Cells |
| Sea Cucumber | 📋 | | | | 36377349 | The synergistic effect of sea cucumber saponins and caffeine on preventing obesity in high-fat diet-fed mice by extending the action duration of caffeine |
| Sesamolin | 📋 | | | | 38228077 | Sesamin and sesamolin potentially inhibit adipogenesis through downregulating the peroxisome proliferator-activated receptor γ protein expression and activity in 3T3-L1 cells |
| Shea | 📋 | | ⛔ | | 33364595 | Hypoglycemic, antidyslipidemic and antioxydant effects of Vitellaria paradoxa barks extract on high-fat diet and streptozotocin-induced type 2 diabetes rats |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 31772594 | Biological Properties and Bioactive Components of Mentha spicata L. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer's Disease, Dermatophytosis, and Drug-Resistant Infections |
| Sunflower Oil | 📋 | ✍ | ⛔ | | 37160801 | Perilla, sunflower, and tea seed oils as potential dietary supplements with anti-obesity effects by modulating the gut microbiota composition in mice fed a high-fat diet |
| Syringic Acid | 📋 | | | | 36235257 | Syringic Acid Ameliorates Cardiac, Hepatic, Renal and Neuronal Damage Induced by Chronic Hyperglycaemia in Wistar Rats: A Behavioural, Biochemical and Histological Analysis |
| Tamarind | 📋 | | ⛔ | | 37048202 | Tamarind Xyloglucan Oligosaccharides Attenuate Metabolic Disorders via the Gut-Liver Axis in Mice with High-Fat-Diet-Induced Obesity |
| Tea Polysaccharides | 📋 | | | | 30622452 | Oolong tea polysaccharide and polyphenols prevent obesity development in Sprague-Dawley rats |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 37375735 | Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome |
| Water Chestnut | 📋 | ✍ | ⛔ | | 35687659 | Effects of water chestnut ( Tarpa bispinosa Roxb.) extract/lutein on fingertip-measured advanced glycation endproduct/carotenoid levels |
| Watermelon | 📋 | | ⛔ | | 37070327 | Blenderized watermelon consumption decreases body mass index, body mass index percentile, body fat and HbA1c in children with overweight or obesity |
| Wenxin Keli | 📋 | ✍ | ⛔ | | 32566078 | Wenxin Granule Ameliorates Hypoxia/Reoxygenation-Induced Oxidative Stress in Mitochondria via the PKC- δ/NOX2/ROS Pathway in H9c2 Cells |
| White Fungus | 📋 | | | | 36545204 | Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota |
| Withanolides | 📋 | | | | 34681241 | Withasomniferol D, a New Anti-Adipogenic Withanolide from the Roots of Ashwagandha ( Withania somnifera) |
| Xylitol | 📋 | ✍ | ⛔ | | 35761691 | Whey protein and xylitol complex alleviate type 2 diabetes in C57BL/6 mice by regulating the intestinal microbiota |
| Aloin | 📋 | | | | 25243866 | Aloin: a natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities |
| Alpha GPC | 📋 | ✍ | ⛔ | | 27861548 | Targeting Mitochondrial Dysfunction with L-Alpha Glycerylphosphorylcholine |
| Apricot Kernels | 📋 | ✍ | ⛔ | | 35055679 | Phytonutrients of Bitter Apricot Seeds Modulate Human Lipid Profile and LDL Subfractions in Adults with Elevated Cholesterol Levels |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 36836723 | Arachidonic Acid Added during the Differentiation Phase of 3T3-L1 Cells Exerts Anti-Adipogenic Effect by Reducing the Effects of Pro-Adipogenic Prostaglandins |
| Asafoetida | 📋 | ✍ | ⛔ | | 30471513 | Antidiabetic and antihyperlipidemic effects of ethanolic Ferula assa-foetida oleo-gum-resin extract in streptozotocin-induced diabetic wistar rats |
| Asiaticoside | 📋 | | | | 38664244 | Asiaticoside alleviates lipopolysaccharide-induced acute lung injury by blocking Sema4D/CD72 and inhibiting mitochondrial dysfunction in RAW264.7 cell and mice |
| Azadirachtin | 📋 | | | | 35794865 | Alterations in Inflammatory Cytokines and Redox Homeostasis in LPS-Induced Pancreatic Beta-Cell Toxicity and Mitochondrial Stress: Protection by Azadirachtin |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 35591766 | Inhalation of low-dose basil (Ocimum basilicum) essential oil improved cardiovascular health and plasma lipid markers in high fat diet-induced obese rats |
| Bee Pollen | 📋 | ✍ | ⛔ | | 33288184 | Effect of antioxidant-rich propolis and bee pollen extracts against D-glucose induced type 2 diabetes in rats |
| Beer | 📋 | | | | 37402233 | Effect of moderate beer consumption (with and without ethanol) on cardiovascular health in postmenopausal women |
| Bell Pepper | 📋 | | ⛔ | | 37446918 | Effects of Capsaicin on Glucose Uptake and Consumption in Hepatocytes |
| Bergamottin | 📋 | | | | 34632552 | Bergamottin protects against LPS-induced endotoxic shock by regulating the NF-κB signaling pathway |
| Beta-Lapachone | 📋 | | | | 31094212 | [Formula: see text] -Lapachone Regulates Obesity through Modulating Thermogenesis in Brown Adipose Tissue and Adipocytes: Role of AMPK Signaling Pathway |
| Bok Choy | 📋 | | ⛔ | | 37355784 | Brassica rapa L. prevents Western diet-induced obesity in C57BL/6 mice through its binding capacity of cholesterol and fat |
| Boron | 📋 | ✍ | ⛔ | | 31109611 | Boron-rich Diet May Regulate Blood Lipid Profile and Prevent Obesity: A Non-Drug and Self-Controlled Clinical Trial |
| Bread | 📋 | | | | 36091225 | The effect of steamed potato-wheat bread intake on weight, lipids, glucose, and urinary Na +/K +: A randomized controlled trial in Chinese adults |
| CAPE | 📋 | | | | 34069954 | Caffeic Acid Phenyl Ester (CAPE) Protects against Iron-Mediated Cellular DNA Damage through Its Strong Iron-Binding Ability and High Lipophilicity |
| Carnosol | 📋 | | | | 33919842 | Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells |
| Catalpol | 📋 | | | | 31797687 | Effect of madecassoside and catalpol in amelioration of insulin sensitivity in pancreatic (INS-1E) β-cell line |
| Cedarwood Essential Oil | 📋 | ✍ | ⛔ | | 37143286 | Cedrol, a major component of cedarwood oil, ameliorates high-fat diet-induced obesity in mice |
| Chebulinic Acid | 📋 | | | | 35055051 | Chebulinic Acid Suppresses Adipogenesis in 3T3-L1 Preadipocytes by Inhibiting PPP1CB Activity |
| Chicoric Acid | 📋 | | | | 37255837 | Chicoric acid ameliorates palmitate-induced sphingosine 1-phosphate signaling pathway in the PBMCs of patients with newly diagnosed type 2 diabetes |
| Cinnamic Acid | 📋 | | | | 36015301 | Cinnamic Acid Attenuates Peripheral and Hypothalamic Inflammation in High-Fat Diet-Induced Obese Mice |
| Citron | 📋 | | ⛔ | | 34710667 | Structurally diverse biflavonoids from the fruits of Citrus medica L. var. sarcodactylis Swingle and their hypolipidemic and immunosuppressive activities |
| Cloudberry | 📋 | | | | 36145221 | Cloudberry ( Rubus chamaemorus L.) Supplementation Attenuates the Development of Metabolic Inflammation in a High-Fat Diet Mouse Model of Obesity |
| Collagen | 📋 | ✍ | | | 37969940 | Low-Molecular Collagen Peptide Supplementation and Body Fat Mass in Adults Aged ≥ 50 Years: A Randomized, Double-Blind, Placebo-Controlled Trial |
| Cryptotanshinone | 📋 | | | | 37509065 | Tanshinone IIA and Cryptotanshinone Counteract Inflammation by Regulating Gene and miRNA Expression in Human SGBS Adipocytes |
| D-Mannose | 📋 | ✍ | ⛔ | | 37246829 | D-mannose reduces adipogenesis by inhibiting the PI3K/AKT signaling pathway |
| Dihydroartemisinin | 📋 | | | | 34847494 | Dihydroartemisinin improves hypercholesterolemia in ovariectomized mice via enhancing vectorial transport of cholesterol and bile acids from blood to bile |
| DIM | 📋 | ✍ | ⛔ | | 34858556 | Dietary glucosinolates inhibit splenic inflammation in high fat/cholesterol diet-fed C57BL/6 mice |
| Docosapentaenoic Acid | 📋 | ✍ | | | 27860326 | Docosapentaenoic acid and docosahexaenoic acid are positively associated with insulin sensitivity in rats fed high-fat and high-fructose diets |
| Dragon Fruit | 📋 | | ⛔ | | 28886195 | Effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: A systematic review and meta-analysis |
| Equol | 📋 | ✍ | ⛔ | | 34749871 | [Lipids-lowering effects of equol on low density lipoprotein receptor knockout hamsters] |
| Eucalyptol | 📋 | | | | 29987888 | Eucalyptol Inhibits Advanced Glycation End Products-Induced Disruption of Podocyte Slit Junctions by Suppressing Rage-Erk-C-Myc Signaling Pathway |
| Eurycomanone | 📋 | | | | 28760530 | Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia |
| Fluted Gourd | 📋 | | | | 34987254 | Anti-hyperlipidemic and antioxidant potentials of aqueous leaf extract of Telfairia occidentalis (fluted pumpkin) in male Sprague-Dawley rats |
| Ganoderic Acid | 📋 | | | | 32686808 | Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet |
| Ginger Essential Oil | 📋 | ✍ | | | 28638882 | POSSIBLE HYPOCHOLESTEROLEMIC EFFECT OF GINGER AND ROSEMARY OILS IN RATS |
| Ginkgolic Acid | 📋 | | | | 30153591 | Ginkgolic acid as a dual-targeting inhibitor for protein tyrosine phosphatases relevant to insulin resistance |
| Ginkgolides | 📋 | | | | 26413119 | Ginkgolide C Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway |
| Glutathione | 📋 | ✍ | ⛔ | | 38397782 | The Role of Glutathione and Its Precursors in Type 2 Diabetes |
| Icaritin | 📋 | | | | 33673187 | The Cholesterol-Lowering Effect of Capsella Bursa-Pastoris Is Mediated via SREBP2 and HNF-1α-Regulated PCSK9 Inhibition in Obese Mice and HepG2 Cells |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 34693116 | Effects of Root Extract of Morinda officinalis in Mice with High-Fat-Diet/Streptozotocin-Induced Diabetes and C2C12 Myoblast Differentiation |
| Iron | 📋 | ✍ | ⛔ | | 35466128 | The role of iron in obesity and diabetes |
| Jackfruit | 📋 | | ⛔ | | 35335251 | Inhibitory Effect of Polyphenols from the Whole Green Jackfruit Flour against α-Glucosidase, α-Amylase, Aldose Reductase and Glycation at Multiple Stages and Their Interaction: Inhibition Kinetics and Molecular Simulations |
| Jasmine | 📋 | | ⛔ | | 36558518 | Cold-Brewed Jasmine Tea Attenuates High-Fat Diet-Induced Obesity and Gut Microbial Dysbiosis |
| Kale | 📋 | | | | 34432833 | Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance |
| Kava Root | 📋 | ✍ | ⛔ | | 35815547 | Relationships of Tobacco Use and Kava Consumption to Sex-Associated Variation in Body Composition and Obesity Risk in Melanesian Adults From Vanuatu |
| L-Lysine | 📋 | ✍ | ⛔ | | 35696944 | Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study |
| L-Methionine | 📋 | ✍ | ⛔ | | 34573099 | L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson's Disease |
| L-Ornithine | 📋 | ✍ | ⛔ | | 37707596 | Combination of tea catechins and ornithine effectively activates the urea cycle: an in vitro and human pilot study |
| L-Threonine | 📋 | ✍ | ⛔ | | 35766226 | Threonine supplementation prevents the development of fat deposition in mice fed a high-fat diet |
| L-Tyrosine | 📋 | ✍ | ⛔ | | 34019348 | [Effect of resveratrol, carnitin, quercetin and aromatic amino acids on the xenobiotic metabolising and antioxidant enzymes in the liver during obesity in rats with different genotypes] |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 32760938 | Dietary citrus peel essential oil ameliorates hypercholesterolemia and hepatic steatosis by modulating lipid and cholesterol homeostasis |
| Lime | 📋 | | ⛔ | | 35215280 | Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders |
| Lime Essential Oil | 📋 | ✍ | ⛔ | | 31500259 | Lime ( Citrus aurantifolia (Christm.) Swingle) Essential Oils: Volatile Compounds, Antioxidant Capacity, and Hypolipidemic Effect |
| Linalool | 📋 | | ⛔ | | 15878236 | Olfactory stimulation with scent of lavender oil affects autonomic nerves, lipolysis and appetite in rats |
| Liquiritin | 📋 | | | | 27810791 | The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibiting NF-κB and MAPK signaling pathway |
| Manganese | 📋 | ✍ | ⛔ | | 37409718 | Protective effect of manganese treatment on insulin resistance in HepG2 hepatocytes |
| Mint | 📋 | | ⛔ | | 37416794 | AGEs Blockerâ„¢ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice |
| MSM | 📋 | ✍ | ⛔ | | 27621186 | Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 36458299 | Hypolipidemic and antioxidant effects of vegetal milk produced with Mucuna pruriens L. seed in rats fed a high-fat diet |
| Mustard | 📋 | | ⛔ | | 36145190 | Anti-Obesogenic Effects of Sulforaphane-Rich Broccoli ( Brassica oleracea var. italica) Sprouts and Myrosinase-Rich Mustard ( Sinapis alba L.) Seeds In Vitro and In Vivo |
| Nimbolide | 📋 | | | | 35491096 | Protective Effect of Nimbolide against High Fat Diet-induced Obesity in Rats via Nrf2/HO-1 Pathway |
| Nitrate | 📋 | ✍ | ⛔ | | 36622081 | Independent, but not co-supplementation with nitrate and resveratrol improves glucose tolerance and reduces markers of cellular stress in high-fat-fed male mice |
| Olive | 📋 | ✍ | ⛔ | | 38089061 | The antihyperlipidemic effect of a combined supplement of standardized dry extracts of amla ( Emblica officinalis), walnut ( Juglans regia), olive ( Olea europaea) and red yeast rice ( Monascus purpureus) powder: Reduction in circulatory low-density lipoprotein-cholesterol (LDL-C) and remnant cholesterol (RC) levels in patients with hypercholesterolemia |
| Omega-9 Fatty Acids | 📋 | | | | 37862824 | A low-carbohydrate diet with different fatty acids' sources in the treatment of obesity: Impact on insulin resistance and adipogenesis |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 32760938 | Dietary citrus peel essential oil ameliorates hypercholesterolemia and hepatic steatosis by modulating lipid and cholesterol homeostasis |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 33429991 | The Antimicrobial Activity of Origanum vulgare L. Correlated with the Gastrointestinal Perturbation in Patients with Metabolic Syndrome |
| Oyster | 📋 | | ⛔ | | 35868410 | Oyster (Crassostrea gigas) polysaccharide ameliorates obesity in association with modulation of lipid metabolism and gut microbiota in high-fat diet fed mice |
| Paeonol | 📋 | | | | 34938364 | Paeonol suppresses lipid formation and promotes lipid degradation in adipocytes |
| Papain | 📋 | ✍ | ⛔ | | 34576066 | Papain Ameliorates Lipid Accumulation and Inflammation in High-Fat Diet-Induced Obesity Mice and 3T3-L1 Adipocytes via AMPK Activation |
| Parsley | 📋 | | ⛔ | | 27069727 | Hepatoprotective effects of parsley, basil, and chicory aqueous extracts against dexamethasone-induced in experimental rats |
| Peas | 📋 | | ⛔ | | 38156281 | Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice |
| Phellodendron | 📋 | ✍ | ⛔ | | 16454147 | Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial |
| Phytoestrogens | 📋 | | ⛔ | | 23318879 | Phytoestrogens and the metabolic syndrome |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 34089294 | The therapeutic effects of Prunella vulgaris against fluoride-induced oxidative damage by using the metabolomics method |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 35678366 | Vitamin B6 rescues insulin resistance and glucose-induced DNA damage caused by reduced activity of Drosophila PI3K |
| Quercitrin | 📋 | | | | 33076582 | Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice |
| Rehmannia | 📋 | ✍ | ⛔ | | 37005841 | [Effects of Rehmanniae Radix and Rehmanniae Radix Praeparata on proteomics and autophagy in mice with type 2 diabetes mellitus induced by high-fat diet coupled with streptozotocin] |
| Rose | 📋 | | | | 37757642 | Rose polyphenols exert antiobesity effect in high-fat-induced obese mice by regulating lipogenic gene expression |
| Rosehip Seed Oil | 📋 | | ⛔ | | 32992796 | Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo |
| Sandalwood Essential Oil | 📋 | | ⛔ | | 34664591 | Sandalwood seed oil improves insulin sensitivity in high-fat/high-sucrose diet-fed rats associated with altered intestinal microbiota and its metabolites |
| Shallot | 📋 | | ⛔ | | 36274534 | The effect of Allium hirtifolium bulb on serum lipid profile in adult patients with hyperlipidemia: A randomized double-blind placebo-controlled clinical trial |
| Shensong Yangxin | 📋 | ✍ | | | 35421806 | Shensong Yangxin attenuates metabolic syndrome-induced atrial fibrillation via inhibition of ferroportin-mediated intracellular iron overload |
| Sirtuin Activators | 📋 | | | | 32848804 | SIRT1 Activation by Natural Phytochemicals: An Overview |
| Sodium Bicarbonate | 📋 | ✍ | ⛔ | | 36699087 | Clinical effectiveness of sodium bicarbonate therapy on mortality for septic patients with acute moderate lactic acidosis |
| Sorghum | 📋 | | ⛔ | | 34572963 | Taxifolin and Sorghum Ethanol Extract Protect against Hepatic Insulin Resistance via the miR-195/IRS1/PI3K/AKT and AMPK Signalling Pathways |
| Spermidine | 📋 | | | | 38185346 | Spermidine activates adipose tissue thermogenesis through autophagy and fibroblast growth factor 21 |
| Spinach | 📋 | | ⛔ | | 37033738 | Spinach ( Spinacia oleracea) microgreen prevents the formation of advanced glycation end products in model systems and breads |
| Sugarcane | 📋 | | ⛔ | | 33123536 | Sugarcane ( Saccharum officinarum L.) Top Extract Ameliorates Cognitive Decline in Senescence Model SAMP8 Mice: Modulation of Neural Development and Energy Metabolism |
| Thyme Essential Oil | 📋 | | ⛔ | | 33995021 | Chemical Composition, Antioxidant Potential, and Blood Glucose Lowering Effect of Aqueous Extract and Essential Oil of Thymus Serrulatus Hochst. Ex Benth |
| Turnip | 📋 | | ⛔ | | 34886781 | Aqueous Extract of Brassica rapa Exerts Antihyperglycemic Activity in Streptozotocin-induced Diabetic Rats |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 10960503 | Effect of pantothenic acid on hippurate formation in sodium benzoate-treated HepG2 cells |
| Vitamins | 📋 | | | | 37817280 | A causal relationship between antioxidants, minerals and vitamins and metabolic syndrome traits: a Mendelian randomization study |
| Yohimbine | 📋 | ✍ | | | 34345380 | Effects of intraperitoneal and intracerebroventricular injection of cinnamaldehyde and yohimbine on blood glucose and serum insulin concentrations in ketamine-xylazine induced acute hyperglycemia |
